About this Research Topic
Throughout the centuries, human beings have relied on Nature to meet their basic needs, including medicines for the treatment of a wide range of diseases. In general, plants have formed the basis of complex traditional systems of medicine. Conventional home-grown prescriptions are of interest, as well as plant-derived substances with negligible, or no mechanical preparation, that have been utilized to treat sickness within local or regional remedial practices. Anticancer drug discovery through natural products could be a difficult task when planning new leads. For years, natural products have acted as a supply of therapeutic agents and have shown supportive uses. Uniquely natural product drug discovery plays a crucial role to develop the scientific evidence of those natural resources.
Natural products are a superb supply of biologically active anticancer molecules that offer several biologically selective options, that can be altered into an innovative creation of synthetic compounds. Natural compounds are characterized by high content of sp3-hybridized carbon atoms; oxygen; spiro, bridged, linked systems; and stereogenic centers, with high structural diversity. To date, many approaches are enforced for mapping and navigating into the chemical range of natural compounds, to explore the various aspects of chemical space. The tactics providing novel prospects to synthesize natural product-enthused compound libraries, involve natural compound-based fragments and ring distortion strategies. These methodologies permit entry to zones of chemical space that are less explored, and accordingly help to overcome the confines in the use of natural compounds in anticancer drug discovery, such as lack of approachability and synthetic intractability.
We encourage contributions on the following topics (but not restricted to):
• Synthetic derivatives of natural anticancer compounds.
• Chemical modification approaches for discovery of new anticancer leads from natural products.
• Biological evaluation of chemically modified natural compounds and their derivatives.
• Synthesis of natural product-inspired scaffolds as potential anticancer drug candidates.
• Natural compound-derived fragments for anticancer drug discovery.
Keywords: natural compounds, synthesis, anticancer, lead generation for new anticancer agents, drug discovery
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.