About this Research Topic
Nano-biotechnology, which integrates nanoscience with biology and biomedicine, has recently attracted great attention in the field of biological analysis. Nanomaterials of various shapes, sizes, and compositions have been developed and extensively utilized, providing exciting possibilities that largely improve our ability to detect biologically relevant events. These breakthroughs include improvements in detection sensitivity and specificity, miniaturization of the sensing platform, and the achievement of high multiplexibility. Despite the many papers that have been published on the topic of nanomaterial-based biosensors and devices, however, very few examples have been successfully used in real clinical settings. The main challenge is to demonstrate the robustness and flexibility of the developed methods and how they could improve the quality of healthcare.
The aim of this Research Topic is to collect Original Research and Review articles that highlight the importance of nanomaterial-based biosensing methods for diagnostic applications, as well as discuss how to use these technologies to resolve real clinical issues. Biological receptors may include antibodies, DNA probes, aptamers, enzymes, molecularly imprinted polymers, glycoproteins, and many other forms of target recognition. Detection modalities may include optical, electrical, electrochemical, acoustic waves, magnetic, and other forms and combinations of signal generation. Applications may include the detection of biomarkers for diagnostic purposes, such as proteins, enzymes, small molecules, circulating tumor cells, and DNA/RNA in biological samples like whole blood, serum, plasma, saliva, cerebral spinal fluid, and urine. Microfluidics, lab-on-chip, and integrated platforms are especially welcome.
Potential themes include, but are not limited to:
• Novel nanomaterials for analyte detection in clinical settings
• Nanomaterial-based biosensor or device validations for diagnostic applications
• Innovative nanomaterial-based biosensing platforms for point-of-care diagnostics
• New strategies that resolves real diagnostic issues using nanotechnology
• Novel nanomaterial-based microfludics for clinical applications
• Reviews of current nanomaterial-based biosensing methods that are applied in diagnostics
Keywords: Nanomaterials, POCT, biosensors, microfludics, diagnostics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.