Research Topic

Multidisciplinary Approach to Uncovering the Pathophysiology of Tourette Syndrome

About this Research Topic

Tourette syndrome (TS) is a neuropsychiatric disorder harboring unique characteristics inclusive of involuntary movements (tics) and neuropsychiatric co-morbidities. Treatment options include pharmacological treatment, cognitive-behavioral therapy, neurofeedback therapy, and neurosurgical intervention. ...

Tourette syndrome (TS) is a neuropsychiatric disorder harboring unique characteristics inclusive of involuntary movements (tics) and neuropsychiatric co-morbidities. Treatment options include pharmacological treatment, cognitive-behavioral therapy, neurofeedback therapy, and neurosurgical intervention.

The onset age of TS is in childhood, however in most cases TS spontaneously subsides by adulthood and only a small group of patients develop the disorder. The biomarkers that predict this disease progression have not yet been established and, additionally, there are many variants of TS with different phenomenologies and psychiatric features. The abnormalities of cortico-striato-thalamo-cortical (CSTC) circuitry have been considered to underlie the mechanisms of the disorder, but the difference among disease sub types remains unknown.

The goal of this Topic is to collect the evidence that sheds light on the underlying problems resulting in various disease sub types of Tourette syndrome. Concerning the differences in phenomenologies among patients, there may be several subtypes involving different neuronal circuits. This Research Topic will aim to collect high-quality research papers addressing new insights of disease mechanisms including abnormal neurocircuitry, disease progression processes from childhood to adulthood, tailored treatment approaches including invasive and non-invasive methods and new technologies. Collection of these scientific papers will address the multidisciplinary issues of unsolved problems associated with TS.

This Research Topic aims to address the multi-disciplinary problems associated with TS from basic to clinical sciences. The following types of articles are welcome: Original Research, Brief Report, Review, Methods, Hypothesis and Theory.


Keywords: Tourette syndrome, neuronal circuit, biomarkers, neurofeedback, neuromodulation


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Submission Deadlines

30 June 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 June 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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