Research Topic

Social Isolation and Post-Stroke Recovery

About this Research Topic

Stroke remains a leading cause of disability despite a decline in stroke-related mortality all over the world. Stroke recovery is affected by several socio-psychological factors. Social support is one of the most recognized psychological factors with the potential to alleviate maladaptive psychological responses to post-stroke stress. In contrast, social isolation (SI) or loneliness exacerbates post-stroke injury and attenuates recovery. Studying the influence of social and emotional factors during stroke recovery has become a growing area for research. Post-stroke depression and anxiety are common clinical findings after stroke, with up to 40% of stroke survivors affected by these deficits. Social isolation further worsens the deficits. The detrimental effects of post-stroke SI have been successfully modeled in the laboratory using mouse model of stroke.

In recent years, the outcomes of several clinical and pre-clinical studies brought attention back to the importance of social interaction or support during recovery from diseases. Keeping these factors in mind, this Research Topic aims to discuss the impact of social isolation on post-stroke recovery. The Research Topic will cover a range of studies that emphasize the effects of social isolation or other socio-psychological factors on stroke recovery.

We welcome authors to contribute original research as well as review articles that will illustrate and stimulate the continuing efforts to better understand the molecular mechanism behind the attenuated recovery in SI after stroke. Identification of these molecular targets may help us to translate targeted social interventions to enhance recovery after stroke.

Themes of interest include:
• Animal models of post-stroke recovery
• Behavioral endpoints to measure post-stroke recovery
• Pathophysiology of post-stroke recovery in social isolation
• Role of neurotrophic factors during post-stroke recovery
• Factors influencing social isolation
• Pharmacological therapy to reduce the detrimental effects of social isolation on stroke recovery
• Role of anxiety and depression on post-stroke recovery
• Role of inflammation in post-stroke social isolation and recovery


Keywords: stroke, animal models, social isolation, stroke recovery


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Stroke remains a leading cause of disability despite a decline in stroke-related mortality all over the world. Stroke recovery is affected by several socio-psychological factors. Social support is one of the most recognized psychological factors with the potential to alleviate maladaptive psychological responses to post-stroke stress. In contrast, social isolation (SI) or loneliness exacerbates post-stroke injury and attenuates recovery. Studying the influence of social and emotional factors during stroke recovery has become a growing area for research. Post-stroke depression and anxiety are common clinical findings after stroke, with up to 40% of stroke survivors affected by these deficits. Social isolation further worsens the deficits. The detrimental effects of post-stroke SI have been successfully modeled in the laboratory using mouse model of stroke.

In recent years, the outcomes of several clinical and pre-clinical studies brought attention back to the importance of social interaction or support during recovery from diseases. Keeping these factors in mind, this Research Topic aims to discuss the impact of social isolation on post-stroke recovery. The Research Topic will cover a range of studies that emphasize the effects of social isolation or other socio-psychological factors on stroke recovery.

We welcome authors to contribute original research as well as review articles that will illustrate and stimulate the continuing efforts to better understand the molecular mechanism behind the attenuated recovery in SI after stroke. Identification of these molecular targets may help us to translate targeted social interventions to enhance recovery after stroke.

Themes of interest include:
• Animal models of post-stroke recovery
• Behavioral endpoints to measure post-stroke recovery
• Pathophysiology of post-stroke recovery in social isolation
• Role of neurotrophic factors during post-stroke recovery
• Factors influencing social isolation
• Pharmacological therapy to reduce the detrimental effects of social isolation on stroke recovery
• Role of anxiety and depression on post-stroke recovery
• Role of inflammation in post-stroke social isolation and recovery


Keywords: stroke, animal models, social isolation, stroke recovery


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

19 June 2020 Abstract
31 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

19 June 2020 Abstract
31 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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