Research Topic

Hype or Hope: New Frontiers in Endometrial Research

About this Research Topic

Differentiation of human endometrial stromal cells (HESCs) into decidual cells represents a highly coordinated process essential for embryo implantation. Following the post ovulatory rise in progesterone levels, HESCs undergo biochemical and morphological transformations in a process known as decidualization.

The process of endometrial decidualization is critical for trophoblast invasion, placental formation and for protecting the early conceptus from environmental stress. Importantly, decidual cells regulate the recruitment of uterine natural killer (uNK) cells to the feto-maternal interface.

Decidualization of the human endometrium, which involves a dramatic morphological and functional differentiation of human endometrial stromal cells (HESCs), is essential for the establishment of a successful pregnancy. Decidualization results from a complex interplay between transcription factors, morphogens, cytokines, cell cycle regulators and signaling pathways. Impairment of the decidualization process is associated with infertility, recurrent miscarriages and pregnancy complication such as pre-eclampsia. Therefore, new awareness regarding decidualization will improve the success rates in ART and open new avenues for treatments in clinical practice.


Despite significant advances in assistive reproductive technology (ART), many couples experience infertility. Implantation rates in ART remain low, even with high‐quality embryos, emphasizing the importance of an impaired decidualization process as a major cause of pregnancy failure and infertility. Deepening our understanding of the complex mechanisms of decidualization will aid in alleviating the many problems that are associated with infertility and improve the success rates of ART.

In this case, the endometrium has been recently studied in regards to the discovery of new biological characteristics, such as identification of genome, transcriptome, microbiome, proteome and metabolomics profiles as well as new potential diagnostic/prognostic biomarkers. This data, taken together, could improve “take home baby” rates.

The scope of this collection is interested in understanding in depth the molecular mechanisms of endometrial decidualization and how deregulation of downstream signalling pathways or cellular function could lead to reproductive failure. We are particularly interested in novel therapeutics that could be used to target reproductive failure.

The section welcomes the following article types: Original Research, Review, Mini-Review, Methods, Perspective, Opinion, Editorial, General Commentary, Data Report, Hypothesis and Theory.

Areas to be covered in this Research Topic may include but are not limited to:

-Actin dynamics
-Transporters and ion channels
-Oxidative stress
-Angiogenesis
-Immune cells
-Epigenetics including miRNA
-Prospects for therapy
-Omics

Articles on cancer will not be considered.


Keywords: Endometrium, Molecular Medicine, Therapuatics and Reproductive Failure, Decidualization


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Differentiation of human endometrial stromal cells (HESCs) into decidual cells represents a highly coordinated process essential for embryo implantation. Following the post ovulatory rise in progesterone levels, HESCs undergo biochemical and morphological transformations in a process known as decidualization.

The process of endometrial decidualization is critical for trophoblast invasion, placental formation and for protecting the early conceptus from environmental stress. Importantly, decidual cells regulate the recruitment of uterine natural killer (uNK) cells to the feto-maternal interface.

Decidualization of the human endometrium, which involves a dramatic morphological and functional differentiation of human endometrial stromal cells (HESCs), is essential for the establishment of a successful pregnancy. Decidualization results from a complex interplay between transcription factors, morphogens, cytokines, cell cycle regulators and signaling pathways. Impairment of the decidualization process is associated with infertility, recurrent miscarriages and pregnancy complication such as pre-eclampsia. Therefore, new awareness regarding decidualization will improve the success rates in ART and open new avenues for treatments in clinical practice.


Despite significant advances in assistive reproductive technology (ART), many couples experience infertility. Implantation rates in ART remain low, even with high‐quality embryos, emphasizing the importance of an impaired decidualization process as a major cause of pregnancy failure and infertility. Deepening our understanding of the complex mechanisms of decidualization will aid in alleviating the many problems that are associated with infertility and improve the success rates of ART.

In this case, the endometrium has been recently studied in regards to the discovery of new biological characteristics, such as identification of genome, transcriptome, microbiome, proteome and metabolomics profiles as well as new potential diagnostic/prognostic biomarkers. This data, taken together, could improve “take home baby” rates.

The scope of this collection is interested in understanding in depth the molecular mechanisms of endometrial decidualization and how deregulation of downstream signalling pathways or cellular function could lead to reproductive failure. We are particularly interested in novel therapeutics that could be used to target reproductive failure.

The section welcomes the following article types: Original Research, Review, Mini-Review, Methods, Perspective, Opinion, Editorial, General Commentary, Data Report, Hypothesis and Theory.

Areas to be covered in this Research Topic may include but are not limited to:

-Actin dynamics
-Transporters and ion channels
-Oxidative stress
-Angiogenesis
-Immune cells
-Epigenetics including miRNA
-Prospects for therapy
-Omics

Articles on cancer will not be considered.


Keywords: Endometrium, Molecular Medicine, Therapuatics and Reproductive Failure, Decidualization


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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