Research Topic

The Role of the Neuro-Immune-Endocrine Network in Chemical Toxicity

About this Research Topic

Over the past few decades, industrialized countries have faced a significant increase of diseases, such as cancer, allergy, autoimmunity, and neurological disorders, including cognitive and other neurodevelopmental deficiencies that can be all linked to immune and neuronal alterations. For instance, increasing evidence points to a significant role for immune dysregulation in autism spectrum disorders (ASD). Moreover, immune molecules have essential functions for several neural developmental processes such as neurogenesis, neuronal migration, axon guidance and synapse formation that if perturbed can lead to dysfunction of the nervous system.
Environmental factors, including hormonally active substances (EDCs), are believed to be a major factor responsible for such increased prevalence. Evidence is accumulating on the existence of multidirectional interactions among immune, nervous and endocrine systems.
The purpose of this special issue is to evaluate experimental evidence supporting the contribution of these interactions in chemical-induced toxicity. Both literature reviews and original scientific articles will be considered. In addition, contributions that consider alternative approaches to animal use, interdisciplinary approaches and mechanistic studies will be considered with much interest.


Keywords: Neurotoxicity, immunotoxicity, endocrine active compounds, xenobiotics, in vitro methods


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Over the past few decades, industrialized countries have faced a significant increase of diseases, such as cancer, allergy, autoimmunity, and neurological disorders, including cognitive and other neurodevelopmental deficiencies that can be all linked to immune and neuronal alterations. For instance, increasing evidence points to a significant role for immune dysregulation in autism spectrum disorders (ASD). Moreover, immune molecules have essential functions for several neural developmental processes such as neurogenesis, neuronal migration, axon guidance and synapse formation that if perturbed can lead to dysfunction of the nervous system.
Environmental factors, including hormonally active substances (EDCs), are believed to be a major factor responsible for such increased prevalence. Evidence is accumulating on the existence of multidirectional interactions among immune, nervous and endocrine systems.
The purpose of this special issue is to evaluate experimental evidence supporting the contribution of these interactions in chemical-induced toxicity. Both literature reviews and original scientific articles will be considered. In addition, contributions that consider alternative approaches to animal use, interdisciplinary approaches and mechanistic studies will be considered with much interest.


Keywords: Neurotoxicity, immunotoxicity, endocrine active compounds, xenobiotics, in vitro methods


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

28 February 2020 Abstract
28 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

28 February 2020 Abstract
28 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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