Research Topic

Ionic Liquid-Based Biopolymers: Design, Synthesis and Characterization

About this Research Topic

Ionic liquids (ILs) have generated a great deal of interest in the chemical industry. The term is used loosely to describe an organic salt with a melting point below 100°C. Ionic liquids have been referred to as "room-temperature molten salt," "low-temperature molten salt," and "liquid organic salts," as unlike conventional salts, they are typically fluid at room temperature. In the race to fabricate new pharmaceutical drugs, ILs have attracted considerable attention due to their amphiphilic nature, which can give rise to considerable enhancements in controlling the aqueous solubility, pharmacokinetic properties, stability, and polymorphism of drug delivery options, or even to customized pharmaceutical cocktails. Moreover, ILs interact with proteins, adding a major fresh landscape to understanding ionic-liquid solution interactions.

With the wide range of cation and anion combinations that are available for different intermolecular balances (and therefore interacting properties) that can become an IL, each amino acid of the protein backbone has the potential for anionic, cationic, hydrophobic, and polar interactions. As a result, much attention has recently been paid to IL-based biopolymers (ILBP), polymeric ionic liquids (PILs), or polyelectrolytes (PEs) due to their remarkable features, which include high thermal and mechanical stabilities, inherent conductivity, excellent electrochemical properties, biocompatibility, and catalytic efficacy.

As such, the goal of this Research Topic will be to investigate new and different research areas concerning the use of natural biopolymers as raw materials for the fabrication of novel ILBPs decorated with nanomaterials, with an aim toward developing new, economically attractive, ecofriendly, and promising bio-architectures that can serve as smart multifunctional pharmacological agents or drug delivery systems. We welcome contributions that investigate, but are not limited to:

 • Design and synthesis of novel biologically active ionic liquid-based biopolymers (ILBPs) and nanobiocomposites (NBCs) with significant potential as new pharmacological agents, tools, probes, or potential drugs
 • Structural and morphological characterization of ILBPs and NBCs based on different techniques (X-ray, SEM, TEM, NMR, etc.)
 • Applications of ILBPs and NBCs as active drug delivery vehicles
 • Theoretical and Structure Activity Relationship (SAR) studies for the identification of target binding sites in ILBPs and NBCs.
 • Applications of third-generation ILs, focusing on extraction processes and chemical analysis procedures.

The Topic Editors would like to acknowledge Professor Sayed Hafez (Suez University, Egypt) and Professor Hussein Khamis Hussein Ali (Alexandria University, Egypt) for their contribution to the development of this Research Topic, as well as for the advisory role they will play in this article collection


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Ionic liquids (ILs) have generated a great deal of interest in the chemical industry. The term is used loosely to describe an organic salt with a melting point below 100°C. Ionic liquids have been referred to as "room-temperature molten salt," "low-temperature molten salt," and "liquid organic salts," as unlike conventional salts, they are typically fluid at room temperature. In the race to fabricate new pharmaceutical drugs, ILs have attracted considerable attention due to their amphiphilic nature, which can give rise to considerable enhancements in controlling the aqueous solubility, pharmacokinetic properties, stability, and polymorphism of drug delivery options, or even to customized pharmaceutical cocktails. Moreover, ILs interact with proteins, adding a major fresh landscape to understanding ionic-liquid solution interactions.

With the wide range of cation and anion combinations that are available for different intermolecular balances (and therefore interacting properties) that can become an IL, each amino acid of the protein backbone has the potential for anionic, cationic, hydrophobic, and polar interactions. As a result, much attention has recently been paid to IL-based biopolymers (ILBP), polymeric ionic liquids (PILs), or polyelectrolytes (PEs) due to their remarkable features, which include high thermal and mechanical stabilities, inherent conductivity, excellent electrochemical properties, biocompatibility, and catalytic efficacy.

As such, the goal of this Research Topic will be to investigate new and different research areas concerning the use of natural biopolymers as raw materials for the fabrication of novel ILBPs decorated with nanomaterials, with an aim toward developing new, economically attractive, ecofriendly, and promising bio-architectures that can serve as smart multifunctional pharmacological agents or drug delivery systems. We welcome contributions that investigate, but are not limited to:

 • Design and synthesis of novel biologically active ionic liquid-based biopolymers (ILBPs) and nanobiocomposites (NBCs) with significant potential as new pharmacological agents, tools, probes, or potential drugs
 • Structural and morphological characterization of ILBPs and NBCs based on different techniques (X-ray, SEM, TEM, NMR, etc.)
 • Applications of ILBPs and NBCs as active drug delivery vehicles
 • Theoretical and Structure Activity Relationship (SAR) studies for the identification of target binding sites in ILBPs and NBCs.
 • Applications of third-generation ILs, focusing on extraction processes and chemical analysis procedures.

The Topic Editors would like to acknowledge Professor Sayed Hafez (Suez University, Egypt) and Professor Hussein Khamis Hussein Ali (Alexandria University, Egypt) for their contribution to the development of this Research Topic, as well as for the advisory role they will play in this article collection


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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