About this Research Topic
Along with the accelerated pace of global population aging, the decline in the cognitive function of the elderly has posed tremendous public health challenges to the society. Cognitive disorders in the elderly, such as Alzheimer’s Disease (AD), its prodromal forms and subtypes as well as other neurodegenerative disorders, appear to be a major manifestation of brain aging.
The brain-immune crosstalk may play a pivotal role in the pathophysiology of AD and other neurodegenerative disorders. A better understanding of this interaction may pave the way to the development of new treatments for neurodegenerative disorders. Recent studies suggest that the gene expression of the innate immune system components is altered during brain aging, especially in AD and that the gene expression changes with the stage of the disease. Amyloid β (Aβ) deposition in the brain activates the immune system, including the brain microglia and peripherally-derived macrophages, monocytes, neutrophils, and NK cells, as well as T cell and B cells, and impairs the capability of microglia, to clear Aβ. These modifications lead to chronic neuroinflammation which contributes to the progression and severity of AD. Further high-quality studies are required for the understanding of the role of the immune system in the onset and progression of AD and other neurodegenerative diseases. New insights in this field will facilitate the identification of potential potent biomarkers and eventually lead to the alleviation, treatment, and prevention of these diseases.
In this Research Topic, we aim to gather the most recent advances on the link between immunological mechanisms and neurodegenerative disorders in the elderly as well as their clinical phenotypes in cross-sectional and longitudinal human studies. We welcome the submission of Original Research, Review, and Perspective articles that address the following sub-topics:
1. Immunological biomarkers of neuronal inflammation in the context of neurodegenerative disorders.
2. Role of innate immunity in Alzheimer’s onset and progression.
3. The most recent immunological studies using novel research technology and methodology for the treatment of neurodegenerative disorders, e.g., using non-invasive exosome vesicles (EVs).
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.