About this Research Topic
The field of Pediatric Nephrology has experienced many successes in the last few decades. Introduction of dialysis and transplantation enabled survival of children with otherwise incurable chronic kidney disease. Advances in pharmacology and drug discovery provided for effective treatments of acute rejection, lupus nephritis, growth failure, hypertension, atypical hemolytic-uremic syndrome and many others. Advances in molecular biology, genetics, bioinformatics and imaging opened new possibilities in early diagnosis and management of array of common nephrologic conditions such as congenital anomalies of kidney and urinary tract (CAKUT), cystic kidney diseases, lupus, hereditary nephritis or hypertension.
Frontiers in Pediatrics section on Pediatric Nephrology has hosted multiple recent Research Topics that offered comprehensive views into some of this progress. However, there still seems to be a need for review information and original research in several “gap” areas that were not covered. For example, recent progress in telemedicine, bioengineering and artificial intelligence (AI) is currently making inroads to clinical practice. Biomarkers of renal dysfunction have reached their destination from bench to patient bedside. New biologics in treatment of lupus, hemolytic uremic syndrome, new renal replacement machines in newborns and preemies are now commercially available. There has been significant progress in our understanding of ApoL1 role in racial disparities and transplant outcomes. New therapies emerged in the treatment of resistant native kidney and recurrent transplant kidney nephrotic syndrome. There is also emerging information on significance and management of white coat, masked and neonatal hypertension. Updates on treatment and classification of Alport syndrome and use of antibiotics in patients with fetal hydronephrosis are useful to every pediatric nephrologists.
In this Research Topic, we propose a comprehensive most up-to-date review of the few selected recent advances in Pediatric Nephrology with a historical perspective on the progress made. We will seek state-of-the art reviews and original manuscripts on those selected topics, which will include renal replacement therapies with emphasis on newborns, biomarkers of renal function in health and disease, telemedicine and AI in nephrology, update on diagnosis and treatment of CAKUT, and selected areas of pediatric cystic kidney diseases, lupus nephritis, Alport, hemolytic uremic syndrome, and childhood hypertension.
We propose that those topics are tackled by junior faculty and hands-on researchers supported by their mentors and primary investigators and we will outreach to the accordingly.
Keywords: CKD, biomarkers, hypertension, HUS, dialysis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.