Research Topic

Stem Cells Secretome in CNS Pathological Conditions

About this Research Topic

One of the biggest challenges in the field of neuroscience research and modeling of central nervous system (CNS) pathologies is the absence of effective compounds for regenerative or neuroprotective strategies. In part, this can be attributed to an ‘one-disease-one-target’ view that has been followed.

Recent advances in stem cell technology have introduced a shift in this paradigm by the use of Stem Cells Secretome (SCS) as a promising therapeutic alternative to the conventional therapies for CNS modeling and repair. In fact, SCS has already shown important (neuro)immunomodulatory actions, as well as effects on other CNS physiological mechanisms, namely on neuronal/glial cell survival, proliferation and differentiation.
However, the current understanding of the molecular and cellular impact of SCS in the CNS remains largely unexplored. Therefore, it is important to further identify potential targets and pathways that explain the mechanistic effects of SCS on CNS regeneration, neuronal survival, and differentiation, neuronal/glial circuits modulation, and to determine how these can be translated to clinical use.

So, the main goal of the present Research Topic is to further understand the cellular and molecular impact of SCS in CNS injury, by exploring the development of novel strategies for CNS repair and functionality.

Therefore, we will welcome Original Research or Review articles from researchers highlighting recent achievements regarding the potential cellular and molecular mechanistic effects of SCS in CNS pathologies by addressing:

• The cellular and molecular impact of SCS in neuronal/glial cell survival, differentiation, protection, function, and restoration.
• The cellular and molecular mechanisms of adaptive responses of the CNS to SCS, addressing regeneration, functionality, and plasticity after its administration.


Keywords: Stem Cells Secretome, Neural repair, CNS injury, Neuroplasticity, Therapeutic strategies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

One of the biggest challenges in the field of neuroscience research and modeling of central nervous system (CNS) pathologies is the absence of effective compounds for regenerative or neuroprotective strategies. In part, this can be attributed to an ‘one-disease-one-target’ view that has been followed.

Recent advances in stem cell technology have introduced a shift in this paradigm by the use of Stem Cells Secretome (SCS) as a promising therapeutic alternative to the conventional therapies for CNS modeling and repair. In fact, SCS has already shown important (neuro)immunomodulatory actions, as well as effects on other CNS physiological mechanisms, namely on neuronal/glial cell survival, proliferation and differentiation.
However, the current understanding of the molecular and cellular impact of SCS in the CNS remains largely unexplored. Therefore, it is important to further identify potential targets and pathways that explain the mechanistic effects of SCS on CNS regeneration, neuronal survival, and differentiation, neuronal/glial circuits modulation, and to determine how these can be translated to clinical use.

So, the main goal of the present Research Topic is to further understand the cellular and molecular impact of SCS in CNS injury, by exploring the development of novel strategies for CNS repair and functionality.

Therefore, we will welcome Original Research or Review articles from researchers highlighting recent achievements regarding the potential cellular and molecular mechanistic effects of SCS in CNS pathologies by addressing:

• The cellular and molecular impact of SCS in neuronal/glial cell survival, differentiation, protection, function, and restoration.
• The cellular and molecular mechanisms of adaptive responses of the CNS to SCS, addressing regeneration, functionality, and plasticity after its administration.


Keywords: Stem Cells Secretome, Neural repair, CNS injury, Neuroplasticity, Therapeutic strategies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

29 July 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

29 July 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..