About this Research Topic
One of the biggest challenges in the field of neuroscience research and modeling of central nervous system (CNS) pathologies is the absence of effective compounds for regenerative or neuroprotective strategies. In part, this can be attributed to an ‘one-disease-one-target’ view that has been followed.
Recent advances in stem cell technology have introduced a shift in this paradigm by the use of Stem Cells Secretome (SCS) as a promising therapeutic alternative to the conventional therapies for CNS modeling and repair. In fact, SCS has already shown important (neuro)immunomodulatory actions, as well as effects on other CNS physiological mechanisms, namely on neuronal/glial cell survival, proliferation and differentiation.
However, the current understanding of the molecular and cellular impact of SCS in the CNS remains largely unexplored. Therefore, it is important to further identify potential targets and pathways that explain the mechanistic effects of SCS on CNS regeneration, neuronal survival, and differentiation, neuronal/glial circuits modulation, and to determine how these can be translated to clinical use.
So, the main goal of the present Research Topic is to further understand the cellular and molecular impact of SCS in CNS injury, by exploring the development of novel strategies for CNS repair and functionality.
Therefore, we will welcome Original Research or Review articles from researchers highlighting recent achievements regarding the potential cellular and molecular mechanistic effects of SCS in CNS pathologies by addressing:
• The cellular and molecular impact of SCS in neuronal/glial cell survival, differentiation, protection, function, and restoration.
• The cellular and molecular mechanisms of adaptive responses of the CNS to SCS, addressing regeneration, functionality, and plasticity after its administration.
Keywords: Stem Cells Secretome, Neural repair, CNS injury, Neuroplasticity, Therapeutic strategies
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.