About this Research Topic
Since its identification as the transcription factor transmitting the glucose signal to the L-type pyruvate kinase promoter in the liver, Carbohydrate-Responsive Element-Binding Protein (ChREBP, gene name MLXIPL, also known as WBSCR14 and MondoB) has been studied as a primary regulator of carbohydrate metabolism. In this central role, ChREBP has been found to possess numerous multifaceted functions, ranging from roles not only in the liver, but also in adipose tissue where a second isoform, ChREBP beta, has been identified, as well as in the islets of Langerhans, and the small intestine. Despite these recent advances in our knowledge of the function of ChREBP, less is known about its basic biology and regulation, of which there have been many suggested promising mechanisms.
This Research Topic will bring together original research and review articles describing recent advances in our understanding of the biology and regulation of this important transcription factor. We are primarily interested in its role in the integrative metabolism of carbohydrate metabolism in health and disease, and are especially interested in the following subtopics:
• Regulation of ChREBP nuclear translocation;
• Regulation of ChREBP transcriptional activation;
• Roles of ChREBP in metabolic diseases including type 2 diabetes and non-alcoholic fatty liver disease (NAFLD);
• Roles of ChREBP in hepatocarcinoma (HCC);
• Roles of ChREBP in non-hepatic tissues, including pancreatic beta cells, the adipose tissue, the kidney and the intestine;
• Studies on ChREBP paralog MondoA.
Keywords: ChREBP, transcription factors, diabetes, lipogenesis
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