About this Research Topic
Cancer is a complex systemic disorder arising from the altered function of multiple cellular and molecular mechanisms. One of the pivotal players in tumor escape and progression is the immune system. Restoring and improving the ability of the immune system to effectively recognize and eradicate cancer is the main focus of immunotherapy, a topic which has recently garnered significant interest. The initial excitement about immunotherapy, however, has been challenged by its limited efficacy in certain patients due to the development of adverse effects such as therapeutic resistance and autoimmunity. At the same time, a number of advances in the field of nanotechnology could potentially address the challenges faced by current immunotherapeutics and allow immunotherapy to increase its clinical success rates.
This Research Topic presents the most recent advances on the emerging technological tools for immunotherapeutic treatment of cancer, including new molecular targets, advanced nanomedicine approaches, and in silico and in vitro systems to predict immunotherapy outcome in patients. Participation with Research papers, short Communications and Reviews focused on these topics are highly encouraged and can range from preparation/synthesis of nanomedicine and molecular tools including their characterization and modelling, up to their in vitro and in vivo applications for immunotherapy. The Research Topic is associated, but not limited to, the results presented within the international workshop "Nanoscience in Cancer Immunotherapy" to be held in Turin on March 11st-13th, 2020. This meeting provides the opportunity for discussion on the most recent advances in tumor immunology, with a focus on nano-bio-technology as a strategy to foster immunotherapy as cancer treatment.
Keywords: Immunotherapy, Nanomedicine, Adjuvant Therapy, Cell Therapy, Drug Delivery, In Vitro Models, Nanoparticles, Cancer Vaccines
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