Research Topic

B Cells in Inflammatory and Neurodegenerative Diseases of the Central Nervous System

About this Research Topic

B cells are critical components of the immune system and have an essential role in the pathogenesis of several diseases of the central nervous system (CNS). Besides producing antibodies, many critical immunoregulatory roles for B cells have been described, including direct effects on the behavior of different cell types of both the adaptive and innate immune systems, or indirect effects through antigen presentation and the production of cytokines which can impact cell differentiation and/or effector functions.

B cells can contribute to neurological disorders either through their actions in the periphery, i.e., through an “outside-in” effect on CNS immunopathology, or following their compartmentalization within the CNS. The local milieu of cytokines in the inflamed CNS promotes B cell migration from the periphery by enhancing B cell chemoattraction and lymphoid organization. Alternatively, in chronically inflamed CNS tissue, B cells form packed aggregates in the meningeal space, some of which seem to be organized and reminiscent of germinal centers. The presence of these meningeal immune cell aggregates, in which B cells can be a prominent feature, has been associated with more aggressive clinical disease and a greater extent of CNS tissue injury in subsets of relatively late-phase progressive multiple sclerosis patients. There have been positive clinical results obtained using B cell depleting therapies in the treatment of multiple sclerosis and other CNS diseases with an autoantibody component, such as neuromyelitis optica and autoimmune encephalitis. This indicates that B cells play a critical role in the pathophysiology of both cellular and humoral-mediated CNS conditions. Emerging evidence also suggests B cells contribute to the pathogenesis of traumatic brain and spinal cord injury, as well as neurodegenerative conditions, including Alzheimer's disease and Parkinson's disease.

Nevertheless, the highly central role of B cells in the immunopathogenesis of CNS disorders has been heretofore not fully recognized, although it is clear these cells, along with their products, may be involved -directly or indirectly- in CNS tissue injury. Hence, advancing our understanding of the basis of B-cell function and dysfunction is of particular interest for the development of new targeted biomarkers and therapies in neurological conditions.

This Research Topic will provide a comprehensive overview of the functions of B cells in the CNS during homeostasis and in the presence of acute and chronic inflammatory and/or neurodegenerative diseases. We welcome the submission of Reviews, Mini-Review, Original Research, Perspective and Commentary articles covering animal and human-based studies that address, among others, the following areas:

• B cell functions in the innate immune system.
• B cell functions in the adaptive immune system.
• Crosstalk between glial cells and B cells.
• B cells and autoantibodies.
• Role of B cells in neuroinflammatory diseases.
• Role of B cells in neurodegenerative diseases.
• B cell adhesion molecules and permeability of the blood-brain barrier
• Ectopic lymphoid follicles and B cell aggregates in the CNS.
• B cell migration into the CNS in health and disease.
• B cell depleting therapies


Keywords: B cells, B lymphocytes, antibodies, neuroinflammation, neurodegeneration, humoral immune response


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

B cells are critical components of the immune system and have an essential role in the pathogenesis of several diseases of the central nervous system (CNS). Besides producing antibodies, many critical immunoregulatory roles for B cells have been described, including direct effects on the behavior of different cell types of both the adaptive and innate immune systems, or indirect effects through antigen presentation and the production of cytokines which can impact cell differentiation and/or effector functions.

B cells can contribute to neurological disorders either through their actions in the periphery, i.e., through an “outside-in” effect on CNS immunopathology, or following their compartmentalization within the CNS. The local milieu of cytokines in the inflamed CNS promotes B cell migration from the periphery by enhancing B cell chemoattraction and lymphoid organization. Alternatively, in chronically inflamed CNS tissue, B cells form packed aggregates in the meningeal space, some of which seem to be organized and reminiscent of germinal centers. The presence of these meningeal immune cell aggregates, in which B cells can be a prominent feature, has been associated with more aggressive clinical disease and a greater extent of CNS tissue injury in subsets of relatively late-phase progressive multiple sclerosis patients. There have been positive clinical results obtained using B cell depleting therapies in the treatment of multiple sclerosis and other CNS diseases with an autoantibody component, such as neuromyelitis optica and autoimmune encephalitis. This indicates that B cells play a critical role in the pathophysiology of both cellular and humoral-mediated CNS conditions. Emerging evidence also suggests B cells contribute to the pathogenesis of traumatic brain and spinal cord injury, as well as neurodegenerative conditions, including Alzheimer's disease and Parkinson's disease.

Nevertheless, the highly central role of B cells in the immunopathogenesis of CNS disorders has been heretofore not fully recognized, although it is clear these cells, along with their products, may be involved -directly or indirectly- in CNS tissue injury. Hence, advancing our understanding of the basis of B-cell function and dysfunction is of particular interest for the development of new targeted biomarkers and therapies in neurological conditions.

This Research Topic will provide a comprehensive overview of the functions of B cells in the CNS during homeostasis and in the presence of acute and chronic inflammatory and/or neurodegenerative diseases. We welcome the submission of Reviews, Mini-Review, Original Research, Perspective and Commentary articles covering animal and human-based studies that address, among others, the following areas:

• B cell functions in the innate immune system.
• B cell functions in the adaptive immune system.
• Crosstalk between glial cells and B cells.
• B cells and autoantibodies.
• Role of B cells in neuroinflammatory diseases.
• Role of B cells in neurodegenerative diseases.
• B cell adhesion molecules and permeability of the blood-brain barrier
• Ectopic lymphoid follicles and B cell aggregates in the CNS.
• B cell migration into the CNS in health and disease.
• B cell depleting therapies


Keywords: B cells, B lymphocytes, antibodies, neuroinflammation, neurodegeneration, humoral immune response


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

17 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

17 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..