About this Research Topic
Globally the prevalence of metabolic syndrome and type-2 diabetes (T2DM) continues to increase. Despite the growing appreciation of the importance of diabetes and metabolic syndrome as major contributors to the increase in heart failure with preserved ejection fraction (HFpEF), the differences between diabetic cardiomyopathy and heart failure states that involve non-obese states and obesity is still unclear. While progress has been made in understanding the changes in glucose and lipid metabolism in lean and obese individuals with T2DM, how the presence or absence of obesity influences the development and progression of heart failure is not well understood.
Diabetes and obesity both have complex influences on myocardial, coronary and more recently, on pulmonary function. Factors that are recognized as being critical to the development of T2DM cardiomyopathy and the progression to HFpEF include inflammatory cytokines and chemokines, an excess of oxidative stress, senescence, the renin-angiotensin-aldosterone, and sympathetic nervous systems and microangiopathy. This Research Topic aims to highlight how obesity or the absence of obesity influence the chronic progression of heart failure associated with diabetes from a cardiopulmonary perspective by not only focusing on common processes but also the points of difference through original articles and reviews of recent findings. We envisage that submitted articles might investigate these differences in cardiopulmonary phenotypes at the organism level, organ and tissue levels, and at the level of the expression of proteins, genes, and RNA. Further, we encourage submissions that consider the potential of novel biomarkers diagnostic of changes in non-obese and obese subjects at early or advanced stages of the disease.
We welcome expressions of interest or abstracts for this Research Topic to confirm that submissions fall within the scope of this topic prior to full submissions.
Keywords: obesity, type-2 diabetes, cardiomyopathy, pulmonary function
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