Research Topic

Biofluid Extracellular Vesicles and Their Involvement in Animal Reproductive Physiology

About this Research Topic

A myriad of locally produced factors influencing the microenvironment of the reproductive tract is regulated through an interactive embryonic-maternal crosstalk. This intercellular communication is known to be regulated and influenced by autocrine, paracrine, and endocrine signaling pathways. Recently, extracellular vesicles (EVs) have emerged as playing a significant role in regulating and facilitating this dialogue. EVs, including exosomes and microvesicles, are membrane-enveloped particles secreted by cells to the surrounding microenvironment and body fluids, and contain proteins, messenger RNA (mRNA), microRNA, and DNA cargoes. Accumulating evidence suggests that EVs are secreted from reproductive cells including oviduct epithelium, placenta, endometrium, embryonic, and ovarian follicular cells, and have pleiotropic effects on both the embryonic and maternal environments. A better understanding of the molecular mechanisms mediating this crosstalk will lead to the development of new regulating agents, with novel diagnostic, biological, and therapeutic potential for either supporting or hindering normal reproductive functions.

The scope of this Research Topic in Frontiers in Veterinary Science includes, but is not limited to, articles covering the following:

- Characterization, contents, and functional roles of EVs in female and male reproductive tissues and biofluids
- Biogenesis and mechanisms of intercellular communication mediated by EVs
- Determination of EVs related biomarkers from biofluids in association with reproductive performance

We would like to welcome researchers and experts in this field to contribute with Original Research, Research Report and/or Review articles that could fit within the scope of this Research Topic.

Dr. Saadeldin holds a patent for transgenic bovine cloned embryos. All other Topic Editors declare no competing interests with regard to the Research Topic subject.


Keywords: Extracellular vesicles, Exosomes, Physiology, Reproduction, Biomarkers


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

A myriad of locally produced factors influencing the microenvironment of the reproductive tract is regulated through an interactive embryonic-maternal crosstalk. This intercellular communication is known to be regulated and influenced by autocrine, paracrine, and endocrine signaling pathways. Recently, extracellular vesicles (EVs) have emerged as playing a significant role in regulating and facilitating this dialogue. EVs, including exosomes and microvesicles, are membrane-enveloped particles secreted by cells to the surrounding microenvironment and body fluids, and contain proteins, messenger RNA (mRNA), microRNA, and DNA cargoes. Accumulating evidence suggests that EVs are secreted from reproductive cells including oviduct epithelium, placenta, endometrium, embryonic, and ovarian follicular cells, and have pleiotropic effects on both the embryonic and maternal environments. A better understanding of the molecular mechanisms mediating this crosstalk will lead to the development of new regulating agents, with novel diagnostic, biological, and therapeutic potential for either supporting or hindering normal reproductive functions.

The scope of this Research Topic in Frontiers in Veterinary Science includes, but is not limited to, articles covering the following:

- Characterization, contents, and functional roles of EVs in female and male reproductive tissues and biofluids
- Biogenesis and mechanisms of intercellular communication mediated by EVs
- Determination of EVs related biomarkers from biofluids in association with reproductive performance

We would like to welcome researchers and experts in this field to contribute with Original Research, Research Report and/or Review articles that could fit within the scope of this Research Topic.

Dr. Saadeldin holds a patent for transgenic bovine cloned embryos. All other Topic Editors declare no competing interests with regard to the Research Topic subject.


Keywords: Extracellular vesicles, Exosomes, Physiology, Reproduction, Biomarkers


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

20 July 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

20 July 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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