About this Research Topic
Although peripheral neuropathies are heterogeneous disorders (i.e. traumatic, genetic or metabolic origin), a common feature underpins these pathologies: the involvement and interaction between glial and immune cells. Neuroimmune crosstalk in peripheral neuropathies occurs both in peripheral and central nervous system and between them. At peripheral level, during Wallerian degeneration, macrophages, mast cells and Schwann cells orchestrate the first phase of neuropathy, in which myelin aggregates, debris are removed by phagocytosis, lipids are recycled, and a wide spectrum of cytokines, chemokines and trophic factors are released. These processes are necessary for nerve regeneration, recovery of functions and chronicization of pain. At a central level, in the early stages of neuropathy development, the presence of damaged primary afferent sensory neurons in the spinal dorsal or ventral horn induces a marked activity of the microglia, which in turn causes astrocytes reactivity. The pro-inflammatory agents released from these cells favor an inflammatory loop that facilitates the central sensitization and drives neuropathic pain. The complex interactions between neurons and glial cells becomes, then, a potential target for treating the chronic pain state.
In this Research Topic we aim to emphasize the importance of neuroimmune interaction as an emerging concept in neuropathy and pain. Our goal is to improve our knowledge on the crosstalk among the different components of immune and nervous systems and its role in the onset and development of neuropathies. We welcome the submission of Original research, Brief Research Report, Review, Mini-Review and Clinical Trial articles conveying recent findings and breakthroughs in the field of neuroimmunology of neuropathies and pain. We expect to cover the following topics relating to peripheral neuropathies and/or neuropathic pain:
• Neuro-immune-glia interaction
• New immune-therapeutic targets and biomarkers
• New molecular mechanisms of neuroinflammation in neuropathies onset, development and maintenance.
• Gender differences and metabolism in immune response
• Age-related differences in neuroimmune response
• Role of immune response in comorbidities
• The environment as a potential hazard in immune reactivity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.