About this Research Topic
The use of plants and their botanical preparations for therapeutic purposes goes back to the beginning of time, probably when early humans, observing animals self-healing behavior, understood the efficacy of plant species. Since then, numerous advances have been discovered, but plant-derived compounds are still positioned as a prospective means rather than concrete tools. Nonetheless plants are currently at the basis of more than one third of drugs and play a key role in cancer, since numerous chemotherapeutic agents have been derived from plants. Endocrine Cancer, as cancer in general, is a challenge for researchers, given its complexity and the strong impact on the endocrine system. The use of plant derived compounds could represent a novel therapeutic approach that should not be underestimated, considering the wide variety of molecules that plants can produce.
The aim of this Research Topic is to provide an overview of the novel phytochemicals investigated in preclinical and clinical models of endocrine cancer. This Research Topic will comprehensively collect new research data on plant derived bioactive molecules, particularly emphasizing their biological, pharmacological, antiproliferative, antimetastatic, anti-inflammatory, antioxidant role in endocrine cancer. Also, clinical studies are welcome if dealing with phytotherapeutic agents tested in human endocrine neoplasms. Moreover, in-depth understanding of the molecular mechanism at the basis of phytochemical effects in endocrine cancer cells is urgently needed, being a key-point for future development of novel drugs. In addition, a specific regard will be dedicated to research exploring the main signaling pathways involved in cancer development, growth and spread (PI3K/AKT, MAPK, Angiogenesis, Apoptosis, Authophagy, Tumor Immunology, Cellular Metabolism).
This Research Topic focuses on original contributions, as research articles, review articles, methods, short communications, or other contributions involving plant derived compounds in endocrine cancer. The works should present cutting-edge scientific advances on the potential interplay between phytochemicals and endocrine cancer, including relevant data in animal models and humans. Potential topics include, but are not limited to:
• Plant natural compounds used to treat common endocrine malignancies, i.e. thyroid cancer, Pancreatic cancer, adrenal cancer, etc.
• Phytotherapeutic agents that can modulate hormonal secretion in endocrine tumors
• Plant extracts with antiproliferative effects in hormone-producing cells of the endocrine system
• Anti-tumor effects with mechanism of action of different plant derived drugs in preclinical models of endocrine malignancies
• Endocrine tumor gland hypo- and hypersecretion modulated by plant derived compounds
• Interaction between phytochemicals and cancer endocrine cell signaling pathways
Keywords: Phytochemicals, cancer, tumor, endocrinology, plant extract, plant metabolites, phytotherapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.