About this Research Topic
Antimicrobial biomaterials are considered an ideal solution to control biomaterial associated infections in tissue engineering applications. The concept of “the race for the surface” between tissue integration and microbial colonization has long been a guide for the development of antimicrobial surfaces with a target-directed action against pathogens. Antimicrobial biomaterials can either counteract the adhesion of microbes, so they cannot attach or grow to the implantable devices, or kill them by delivering active concentrations of bactericidal substances, and thus, ultimately hamper microbial colonization and biofilm assembly. In recent years, many breakthroughs have been achieved in this area with the development of multiple-function coatings that not only play an antibacterial role but also tissue integrating functions; hence, reducing infection and healing time via target-directed actions that respond to the environmental stimuli.
Biofilms formed by pathogenic microorganisms are highly complex and dynamic multicellular communities that cause up to 75% of all bacterial infections. Even though solutions resorting to antimicrobial biomaterials have been proposed, there is still much to be learned about the pathogen's way of action and a need to find new ways to improve the biomaterials' surface. This topic seeks to further our understanding of the antimicrobial action of specialized biomaterials, the alterations that can be made to the biomaterials' surface and to what extent infection control can be attained without losing the regenerative capacities of the biomaterial. The search for advanced target-directed platforms that display specific functions against pathogens but remain active by stimulating cell response and tissue healing, in a single biomaterial formulation, is the main goal of this Research Topic.
The aim of this Research Topic is to cover promising, recent, and novel research trends in the field of antimicrobial biomaterials research. Reviews on specific topics with this field will also be accepted. Areas to be covered in this Research Topic may include, but are not limited to:
• Engineering of new antimicrobial biomaterials;
• Surface modification;
• Multi-functional coatings;
• Antimicrobial agents (-static and -cidal);
• Target-directed biomolecules (e.g. responsive to environmental stimuli)
Keywords: Antimicrobial action, Surface modification, Biofunctionalization, Multi-functional coatings, Target-directed biomolecules
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