Research Topic

Resistance to Medical Therapy in Pituitary Tumors

About this Research Topic

In the era of personalized target therapies, patients with pituitary tumors may display resistance to conventional medical treatments, including somatostatin analogs (SA) and dopamine agonists (DA). Resistance to medical treatment generally leads to multi-modal therapy including surgery and radiotherapy, but tumors frequently relapse after radical surgical excision. Such a phenomenon is of crucial interest, as it occurs in up to two thirds of patients with pituitary tumors and is nowadays considered predictive of aggressive behavior of the tumor, therefore associated with poor prognosis and increased mortality. Predictors of responsiveness to medical treatments are still under investigation, and no clear clinical factor has been identified to drive endocrinologists through the choice of the best individualized medical therapy in patients with pituitary malignancies.

This Research Topic will focus on resistance in medical therapy in pituitary tumors, and will address molecular and genetic mechanisms hypothesized to explain the resistance to SA and DA treatment, and consequent clinical implications. We welcome reviews and original research focusing on the following:

• The expression of somatostatin and dopamine receptors in normal and tumoral pituitary, molecular, and genetic mechanisms of resistance, and clinical consequences,
• Future therapeutic perspectives for patients.


Keywords: Pituitary, tumor, resistance, medical therapy, aggressive tumors


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

In the era of personalized target therapies, patients with pituitary tumors may display resistance to conventional medical treatments, including somatostatin analogs (SA) and dopamine agonists (DA). Resistance to medical treatment generally leads to multi-modal therapy including surgery and radiotherapy, but tumors frequently relapse after radical surgical excision. Such a phenomenon is of crucial interest, as it occurs in up to two thirds of patients with pituitary tumors and is nowadays considered predictive of aggressive behavior of the tumor, therefore associated with poor prognosis and increased mortality. Predictors of responsiveness to medical treatments are still under investigation, and no clear clinical factor has been identified to drive endocrinologists through the choice of the best individualized medical therapy in patients with pituitary malignancies.

This Research Topic will focus on resistance in medical therapy in pituitary tumors, and will address molecular and genetic mechanisms hypothesized to explain the resistance to SA and DA treatment, and consequent clinical implications. We welcome reviews and original research focusing on the following:

• The expression of somatostatin and dopamine receptors in normal and tumoral pituitary, molecular, and genetic mechanisms of resistance, and clinical consequences,
• Future therapeutic perspectives for patients.


Keywords: Pituitary, tumor, resistance, medical therapy, aggressive tumors


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

27 May 2020 Abstract
30 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

27 May 2020 Abstract
30 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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