Research Topic

Enzyme Inhibitors from Venoms and Plant Natural Biomolecules as Therapeutics

About this Research Topic

Through several hundred million years of adaptive evolution venomous animal species and toxic plants have developed a large group of high-affinity and stable natural-based biomolecules, which have now been isolated and identified. Some of these biomolecules possess the ability to specifically bind to human receptors/ligands, which means they have a great potential to be used as novel prototype drug candidates for disease treatments such as hypertension, cancer, diabetes, drug-resistant bacterial infections, etc. In the last two decades, much biomolecular research has been focused on certain types of distinctive molecular targets on cells, which can be recognized by natural-based biomolecules, to unveil their use in different aspects of clinical prognosis and therapeutic applications. However, the majority of those natural-based prototype drugs entering clinical trials are still struggling due to the fact that their modes of action are not fully identified, and more lab-based and preclinical work needs to be done to further this research direction.

This Research Topic aims to bring together leading researchers to exchange and share their findings on the hot topics of novel identified venom- and/or plant-derived natural biomolecules with potent pharmacological activity and their corresponding molecular mechanisms. We aim to fill the gap which is hindering their potential use as novel prototype drug candidates for the treatment of diseases such as hypertension, cancer, diabetes and drug-resistant bacterial/viral infections.

The key areas which we would like to discuss in this Research topic include the isolation, structural identification, and activity evaluation of novel antimicrobial biomolecules against ESKAPE pathogens, smooth muscle contractile agonists/antagonists, serine protease inhibitors, and/or anticancer biomolecules. We would also like to discuss the investigation of their mechanisms for targeted therapies and/or precision treatments.

We welcome all investigators to submit Original Research, Reviews, and Perspectives on the areas of:

• Venom-derived biomolecules; including peptides and protease for anticancer, antimicrobial, antifungal, antiviral, diabetes, hypertension treatments and degenerative disease treatments

• Plant-based biomolecules; including plant-derived dietary factors, alkaloids, proteins for anticancer, antimicrobial, antifungal, antiviral, diabetes, hypertension treatments and degenerative disease treatments


Doctors Kwok and Chen hold patents related to Vasodilator and pro-angiogenic peptides.


Keywords: Natural bioactive compounds, Phytochemicals, Diseases, Diagnosis, Precision treatments, Targeted therapies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Through several hundred million years of adaptive evolution venomous animal species and toxic plants have developed a large group of high-affinity and stable natural-based biomolecules, which have now been isolated and identified. Some of these biomolecules possess the ability to specifically bind to human receptors/ligands, which means they have a great potential to be used as novel prototype drug candidates for disease treatments such as hypertension, cancer, diabetes, drug-resistant bacterial infections, etc. In the last two decades, much biomolecular research has been focused on certain types of distinctive molecular targets on cells, which can be recognized by natural-based biomolecules, to unveil their use in different aspects of clinical prognosis and therapeutic applications. However, the majority of those natural-based prototype drugs entering clinical trials are still struggling due to the fact that their modes of action are not fully identified, and more lab-based and preclinical work needs to be done to further this research direction.

This Research Topic aims to bring together leading researchers to exchange and share their findings on the hot topics of novel identified venom- and/or plant-derived natural biomolecules with potent pharmacological activity and their corresponding molecular mechanisms. We aim to fill the gap which is hindering their potential use as novel prototype drug candidates for the treatment of diseases such as hypertension, cancer, diabetes and drug-resistant bacterial/viral infections.

The key areas which we would like to discuss in this Research topic include the isolation, structural identification, and activity evaluation of novel antimicrobial biomolecules against ESKAPE pathogens, smooth muscle contractile agonists/antagonists, serine protease inhibitors, and/or anticancer biomolecules. We would also like to discuss the investigation of their mechanisms for targeted therapies and/or precision treatments.

We welcome all investigators to submit Original Research, Reviews, and Perspectives on the areas of:

• Venom-derived biomolecules; including peptides and protease for anticancer, antimicrobial, antifungal, antiviral, diabetes, hypertension treatments and degenerative disease treatments

• Plant-based biomolecules; including plant-derived dietary factors, alkaloids, proteins for anticancer, antimicrobial, antifungal, antiviral, diabetes, hypertension treatments and degenerative disease treatments


Doctors Kwok and Chen hold patents related to Vasodilator and pro-angiogenic peptides.


Keywords: Natural bioactive compounds, Phytochemicals, Diseases, Diagnosis, Precision treatments, Targeted therapies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

19 June 2020 Abstract
30 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

19 June 2020 Abstract
30 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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