Research Topic

Engineered Tissue Models and Phenomics for Personalized Medicine

About this Research Topic

Personalized medicine aims to move away from a “one size fits all” approach to the treatment of various diseases in patients in recognition that there exists variation between individuals or specific populations. The current paradigm for personalizing disease treatment relies on molecular profiling approaches to identify biomarkers that can stratify patients. However, there are some caveats with a biomarker-based approach to personalized medicine – biomarkers are not available for all disease indications and developing new biomarkers that are targetable can take a very long time.

Based on the tenet that the best prediction of treatment response is treatment response itself, engineered tissue models generated using patient-derived cells can be used as patient surrogates to directly test various therapies on. This would require advancement in the design of tissue engineering strategies to specifically support and maintain patient-derived cells/tissues in a platform that is scalable for drug testing applications. New phenotypic assays compatible with the engineered tissue platform must also be developed to functionally measure differential responses to various therapeutic modality. Finally, systematic validation studies correlating in vitro response results to that of in vivo or clinical testing would be critical to determine the predictive value of the engineered tissue models.

We welcome the following themes:
• Biomaterials, biofabrication and cell culture technologies tailored for the maintenance of patient-derived cells (i.e. primary and iPSC-derived cells) and tissues
• Engineered artificial microenvironments to mimic tissue microenvironment
• Drug testing platform and studies using patient-derived models
• Phenomics
• In vitro-in vivo/clinical validation studies


Keywords: phenomics, tissue models, bioengineering, personalized


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Personalized medicine aims to move away from a “one size fits all” approach to the treatment of various diseases in patients in recognition that there exists variation between individuals or specific populations. The current paradigm for personalizing disease treatment relies on molecular profiling approaches to identify biomarkers that can stratify patients. However, there are some caveats with a biomarker-based approach to personalized medicine – biomarkers are not available for all disease indications and developing new biomarkers that are targetable can take a very long time.

Based on the tenet that the best prediction of treatment response is treatment response itself, engineered tissue models generated using patient-derived cells can be used as patient surrogates to directly test various therapies on. This would require advancement in the design of tissue engineering strategies to specifically support and maintain patient-derived cells/tissues in a platform that is scalable for drug testing applications. New phenotypic assays compatible with the engineered tissue platform must also be developed to functionally measure differential responses to various therapeutic modality. Finally, systematic validation studies correlating in vitro response results to that of in vivo or clinical testing would be critical to determine the predictive value of the engineered tissue models.

We welcome the following themes:
• Biomaterials, biofabrication and cell culture technologies tailored for the maintenance of patient-derived cells (i.e. primary and iPSC-derived cells) and tissues
• Engineered artificial microenvironments to mimic tissue microenvironment
• Drug testing platform and studies using patient-derived models
• Phenomics
• In vitro-in vivo/clinical validation studies


Keywords: phenomics, tissue models, bioengineering, personalized


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

14 August 2020 Abstract
13 January 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

14 August 2020 Abstract
13 January 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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