Research Topic

Acute Myeloid Leukemia (AML) Therapy: Adapting to Change

About this Research Topic

Acute myeloid leukemia (AML) is a heterogeneous malignancy characterized by recurrent genetic, epigenetic, and metabolic abnormalities. Historically, prognosis is relatively poor with long-term overall survival (OS) achieved in approximately 40% of young adults, and only 10-15% of elderly patients (>65 years) with AML. As a matter of fact, most AML patients are either primary refractory to induction therapy, or subsequently relapse following a brief remission likely due to persistence of chemo-resistant leukemia stem cells or low volume minimal residual disease. However, major breakthroughs have been achieved in deciphering the genetic landscape of AML and its impact on prognostication, therapy selection, and outcomes in patients with AML.

Accordingly, the therapeutic armamentarium of AML has rapidly progressed in the past few years, driven largely by translational research into its genomic landscape, and an improved understanding of mechanisms of resistance to conventional therapies. As a result of our increasing knowledge of the underlying biology of AML leading to rational drug development, several new targeted agents have been recently added to our therapeutic arsenal, and the treatment landscape has changed substantially since 2017. New targeted drugs have emerged, including venetoclax, midostaurin, gilteritinib, ivosidenib, enasidenib, gemtuzumab ozogomycin, glasdegib, and a liposomal formulation of daunorubicin and cytarabine (CPX-351). For decades, treatment decisions have largely centered around chemotherapy drug intensity. Physicians now have access to an increasing number of drugs with novel mechanisms of action and distinctive side-effect profiles.

This research topic will be focusing on the efficacy of novel therapeutics and promising combination approaches to further improve outcomes in the treatment of patients with AML. We welcome the submission of Original Research, Review and Clinical Trial articles.


Keywords: Acute Myeloid Leukemia, Patient Care, Patient Outcomes, Novel Therapies, Combination Therapies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Acute myeloid leukemia (AML) is a heterogeneous malignancy characterized by recurrent genetic, epigenetic, and metabolic abnormalities. Historically, prognosis is relatively poor with long-term overall survival (OS) achieved in approximately 40% of young adults, and only 10-15% of elderly patients (>65 years) with AML. As a matter of fact, most AML patients are either primary refractory to induction therapy, or subsequently relapse following a brief remission likely due to persistence of chemo-resistant leukemia stem cells or low volume minimal residual disease. However, major breakthroughs have been achieved in deciphering the genetic landscape of AML and its impact on prognostication, therapy selection, and outcomes in patients with AML.

Accordingly, the therapeutic armamentarium of AML has rapidly progressed in the past few years, driven largely by translational research into its genomic landscape, and an improved understanding of mechanisms of resistance to conventional therapies. As a result of our increasing knowledge of the underlying biology of AML leading to rational drug development, several new targeted agents have been recently added to our therapeutic arsenal, and the treatment landscape has changed substantially since 2017. New targeted drugs have emerged, including venetoclax, midostaurin, gilteritinib, ivosidenib, enasidenib, gemtuzumab ozogomycin, glasdegib, and a liposomal formulation of daunorubicin and cytarabine (CPX-351). For decades, treatment decisions have largely centered around chemotherapy drug intensity. Physicians now have access to an increasing number of drugs with novel mechanisms of action and distinctive side-effect profiles.

This research topic will be focusing on the efficacy of novel therapeutics and promising combination approaches to further improve outcomes in the treatment of patients with AML. We welcome the submission of Original Research, Review and Clinical Trial articles.


Keywords: Acute Myeloid Leukemia, Patient Care, Patient Outcomes, Novel Therapies, Combination Therapies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

07 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

07 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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