About this Research Topic
Soft tissues form a large part of the human body including, internal organs, muscles, and blood vessels. They play a critical role in many aspects of life and some of them, such as the skin, also protect the body against the dangerous external pathogens. Soft tissues are continuously exposed to damages (e.g., burns and mechanical traumas) and, thereby, thousands of people need remedial interventions such as biomaterials-based therapies. On this subject, the use of bioceramics and relevant composites have been recently proposed to accelerate the healing process considering their excellent properties including the ability to provide an appropriate environment for cell proliferation and differentiation. Specific types and formulations of bioceramics, either alone or in combination of other materials (polymers), have been evaluated for the management of soft tissue damages and showed satisfactory results both in vitro and in vivo.
The main goal of the present Research Topic is to highlight the recent advances in the field of bioceramics and relevant composites applied for soft tissue healing strategies. Although bioceramics are mainly used to treat hard tissue injuries (e.g., bone defects), molecular and cellular interactions between them and soft tissues have always been of great interest due to the proximity of hard and soft tissues in the human body. Moreover, distinct types of bioceramics including hydroxyapatite (HAp), bioactive glasses (BGs) and carbon nanomaterials are showing great promise in accelerating soft tissue healing process too. Therefore, how bioceramics interact with somatic and stem cells derived from soft tissues should be considered as an important topic when optimal regeneration is needed. Overall, in order to show the current state of bioceramics and explore the future of bioceramics in soft tissue repair and regeneration, it seems necessary to gather a collection of studies focusing on this important issue.
In brief, all papers dealing with repair and regeneration of the skin, cardiovascular & pulmonary system, peripheral nerve, muscle, liver, digestive system, urogenital system and other internal organs/structures by using bioceramics and relevant composites are welcome in this Research Topic. This collection will include innovative synthesis approaches and fabrication processes, characterization strategies, modelling, in vitro interactions, and in vivo outputs of bioceramics.
Special focus will be given (but is not restricted) to:
• Calcium phosphates for soft tissue healing
• Bioactive glasses in the management of soft tissue injuries
• Carbon nanomaterials in soft tissue repair and regeneration
• Bioceramic-polymer composites as soft tissue replacements
• Bioceramic-based drug delivery systems for soft tissue healing
• Bioceramic-based interfacial hard/soft tissue engineering
Drs. Saeid Kargozar and Francesco Baino hold patents related to ceramics. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Soft Tissue Healing, Bioceramics, Bioactive Glasses, Polymer-Based Composites, Nanomaterials
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.