Research Topic

Endocrinology of Gender Dysphoria

About this Research Topic

Gender dysphoria (GD) is a state of distress caused by incongruence between a person’s gender identity and their assigned sex at birth. Gender identity reflects a complex interplay of biological, environmental, and cultural factors and the origin of GD could be multifactorial: in addition to the psychological and socio-cultural factors, some interesting endocrinological hypotheses have emerged. Gender affirming hormone therapy has the main goal of alleviating GD by replacing endogenous hormones with those of the asserted/expressed gender.

The aim of this Research Topic is to provide a review of the published literature on the multidisciplinary approach to gender dysphoria during the lifespan: etiopatogenetic hypotheses, diagnosis, psychological and endocrinological management, psychiatric issues, quality of life and sexual function, gender-confirming surgery.

A specific part will be dedicated to the known hypotheses of gender dysphoria genesis. How sexual hormones influence gender identity development will be included. Particular issues such as fertility preservation, cardiovascular risk, cancer risk, and social aspects (e.g sport participation and competitive sport policies) will be included.

This Research Topic will provide all professionals involved in the management of gender dysphoria in pediatric age, adulthood, and aging an up-to-date and comprehensive literature review useful in their clinical practice. The Research Topic will consist of a number of short reviews focusing on the most interesting and relevant articles published recently in the field.

Themes of interest include the following:
• Determinants of gender identity development
• Gender dysphoria: definition and diagnosis
• Psychological management of gender dysphoria
• Gender affirming treatment in pediatric and adult patients
• Gender-confirming surgery
• Quality of life and sexual function in transgender persons
• Particular topics mentioned prior


Keywords: Gender dysphoria, transgender, transsexual, sex steroids, sexual function


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Gender dysphoria (GD) is a state of distress caused by incongruence between a person’s gender identity and their assigned sex at birth. Gender identity reflects a complex interplay of biological, environmental, and cultural factors and the origin of GD could be multifactorial: in addition to the psychological and socio-cultural factors, some interesting endocrinological hypotheses have emerged. Gender affirming hormone therapy has the main goal of alleviating GD by replacing endogenous hormones with those of the asserted/expressed gender.

The aim of this Research Topic is to provide a review of the published literature on the multidisciplinary approach to gender dysphoria during the lifespan: etiopatogenetic hypotheses, diagnosis, psychological and endocrinological management, psychiatric issues, quality of life and sexual function, gender-confirming surgery.

A specific part will be dedicated to the known hypotheses of gender dysphoria genesis. How sexual hormones influence gender identity development will be included. Particular issues such as fertility preservation, cardiovascular risk, cancer risk, and social aspects (e.g sport participation and competitive sport policies) will be included.

This Research Topic will provide all professionals involved in the management of gender dysphoria in pediatric age, adulthood, and aging an up-to-date and comprehensive literature review useful in their clinical practice. The Research Topic will consist of a number of short reviews focusing on the most interesting and relevant articles published recently in the field.

Themes of interest include the following:
• Determinants of gender identity development
• Gender dysphoria: definition and diagnosis
• Psychological management of gender dysphoria
• Gender affirming treatment in pediatric and adult patients
• Gender-confirming surgery
• Quality of life and sexual function in transgender persons
• Particular topics mentioned prior


Keywords: Gender dysphoria, transgender, transsexual, sex steroids, sexual function


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

01 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

01 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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