About this Research Topic
In recent years a growing number of genes (GDI1, RAB39B, FMR1, CDH8-10, MAPK3, SHANK3, NLGN3, DAT, COMT, SERT, HTR1B among many others) have been implicated in the etiopathogenesis of Neurodevelopmental Disorders (NDDs). NDDs with the highest incidence are Autism Spectrum Disorder (ASD), Intellectual Disability (ID) and Attention Deficit Hyperactivity Disorder (ADHD). Other NDDs such as antisocial behaviors (Antisocial Personality Disorder) have received less attention. The prevalence and severity of all these NDDs seem to be the results of Genes x Environment interactions.
The role of peri and post-natal environmental conditions on the incidence and severity of NDDs has not been fully understood and might be key to the deployment of more efficacious therapies combining pharmacological and environmental interventions.
This Research Topic will welcome contribution focusing on the elucidation of the molecular mechanisms underlying peripheral and central responsivity to environmental cues and adversities involved in NDDs.
Themes of interest include but are not limited to:
• Dissect specific effects of environmental conditions that modify the association between the genetic background NDDs.
• Identify and elucidate the molecular mechanisms by which these Gene x Environment interactions exert their effect in NDDS.
• Propose novel pharmacological, environmental or combined strategies to provide effective and efficacious treatments.
Image credit: Mind the Graph (CC-BY)
Keywords: Gene x Environment, NDDs, molecular mechanism, treatments