About this Research Topic
During embryonic development, several signaling pathways are activated in a very well-orchestrated manner. This highly controlled activation is important to allow the formation of a multicellular organism from a simple single cell. Embryogenesis involves the meticulous governance of cellular proliferation, migration, and differentiation. These are fundamental processes for the appropriate formation of the organs and tissues at the correct place and time in a human being.
To this end, several crucial signaling pathways orchestrate cellular responses of the embryo in a very coordinated manner. Signaling molecules such as Sonic Hedgehog (SHH); WNT; Fibroblast growth factor (FGF); NOTCH, members of transforming growth factor-beta (TGF-β) family, and others are responsible for the perfect transformation of a cluster of cells into a precise machine composed of diverse types of cells that provide all functions that a human being needs to live. However, due to their expression and importance as regulators throughout the body, failure in developmental genes often leads to marked defects or severe pathologies, such as cancer, cardiac disease; metabolic diseases or craniofacial malformation syndromes, (chronic) inflammatory, autoimmune, degenerative and other diseases.
In this Research Topic, we aim to present high-quality research about developmental genes and molecular approaches providing the recent advances concerning embryo development to human diseases, such as neurodevelopmental disorders including Autism Spectrum Disorders (ASD); Alagille syndrome, Alzheimer’s disease; Apert syndrome, Pallister-Hall syndrome; Situs ambiguous, several types of cancer such as Glioblastoma, breast, lung and prostate. We are interested in Original and Review articles that further our understanding of this fascinating topic.
Keywords: Signaling pathways, Molecular biology, Organogenesis, Tumorigenesis, Human diseases
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