About this Research Topic
Despite the initial success of antibiotics, currently, the loss of their efficacy is leading to a serious global health crisis due to the increasing frequency of multi- and pan-drug resistant bacteria. Hence, it is mandatory to develop new antibiotics or otherwise new alternatives to combat bacterial infections in order to avoid the prediction that by the year 2050, untraceable infections, mainly from ESKAPE pathogens, will cause 10 million human deaths per year.
Among the alternative approaches to the utilization of classical antibiotics the following have been explored:
a) anti-virulence therapies focused in “disarming” bacterial pathogens rather than killing them,
b) Trojan horse strategies using non metabolizable analogues of iron i.e. other metals (such as Gallium), and other important nutrients,
c) physical therapies like using far UV-light and the utilization of photosensitizers.
This Research Topic welcomes the submission of Original Research, Hypothesis and Theory, Reviews, and Opinion manuscripts dealing with the alternatives mentioned above, but the topic is not restricted to them. We especially encourage authors to submit Original Research articles, using multi- and pan-drug resistant strains and in vivo experiments, as well as hypothesis and perspective manuscripts about the current situation and how to improve the current ways of treating bacterial infections.
Keywords: antibiotic resistance, anti-virulence, quorum quenching, photosensitizers, Trojan horses
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