About this Research Topic
The best-known disease-associated genetic factors in autoimmune diseases are mapped to the MHC II locus, which has prompted the scientific community to examine the CD4+ T helper cells in great detail. Interestingly, many autoimmune diseases (such as many rheumatic diseases and multiple sclerosis) are also linked to classical and non-classical MHC I alleles, highlighting the importance of CD8+ lymphocytes in the induction, regulation and progression of autoimmune inflammation. MHC I play an important role in controlling viral infections, which are well known risk factors for many autoimmune diseases (e.g. Epstein-Barr virus in multiple sclerosis and rheumatic disease). Furthermore, it is also known that CD8+ lymphocytes are overrepresented in the acute multiple sclerosis brain lesions as well as in the synovial tissue isolated from patients with autoimmune arthritis. Results from recent studies utilizing modern high-through put methods have further strengthened the concept of CD8+ lymphocytes as important regulators and effectors of autoimmune inflammation.
This Research Topic is focused on the role of CD8+ cytotoxic lymphocytes in chronic, non-infectious inflammation and will provide a comprehensive overview of these timely issues with a particular emphasis on neuroinflammatory and rheumatic diseases. We welcome submissions of Original Research, Perspective, Clinical Trial, Case Report and Review articles on human and/or animal studies that cover, but are not limited to, the following topics:
1. Mechanisms of CD8+ lymphocyte mediated disease progression and/or regulation in central and peripheral nervous system inflammation.
2. CD8+ lymphocytes as inflammation modulators in rheumatic diseases (including myositis).
3. Interaction of CD8+ lymphocytes and class I MHC molecule mediated antigen presentation.
4. CD8+ lymphocyte immune repertoires and disease associated CD8+ lymphocyte biomarkers in nervous system inflammation and rheumatic diseases.
5. MHC I allelic variation and expression in nervous system inflammation and rheumatic diseases (including myositis).
6. Therapeutic approaches to modulate autoimmune inflammation via CD8+ lymphocytes.
Dr. Pizzolla receives financial support from Roche-Genentech. The other Topic Editors declare no competing interests with regards to the Research Topic theme.
Keywords: Adaptive immunity, Cytotoxic lymphocyte, CD8+ lymphocyte, CNS inflammation, rheumatic disease
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