Research Topic

CD8+ Lymphocytes in Rheumatic Diseases and in Neuroinflammation

About this Research Topic

The best-known disease-associated genetic factors in autoimmune diseases are mapped to the MHC II locus, which has prompted the scientific community to examine the CD4+ T helper cells in great detail. Interestingly, many autoimmune diseases (such as many rheumatic diseases and multiple sclerosis) are also linked to classical and non-classical MHC I alleles, highlighting the importance of CD8+ lymphocytes in the induction, regulation and progression of autoimmune inflammation. MHC I play an important role in controlling viral infections, which are well known risk factors for many autoimmune diseases (e.g. Epstein-Barr virus in multiple sclerosis and rheumatic disease). Furthermore, it is also known that CD8+ lymphocytes are overrepresented in the acute multiple sclerosis brain lesions as well as in the synovial tissue isolated from patients with autoimmune arthritis. Results from recent studies utilizing modern high-through put methods have further strengthened the concept of CD8+ lymphocytes as important regulators and effectors of autoimmune inflammation.

This Research Topic is focused on the role of CD8+ cytotoxic lymphocytes in chronic, non-infectious inflammation and will provide a comprehensive overview of these timely issues with a particular emphasis on neuroinflammatory and rheumatic diseases. We welcome submissions of Original Research, Perspective, Clinical Trial, Case Report and Review articles on human and/or animal studies that cover, but are not limited to, the following topics:

1. Mechanisms of CD8+ lymphocyte mediated disease progression and/or regulation in central and peripheral nervous system inflammation.
2. CD8+ lymphocytes as inflammation modulators in rheumatic diseases (including myositis).
3. Interaction of CD8+ lymphocytes and class I MHC molecule mediated antigen presentation.
4. CD8+ lymphocyte immune repertoires and disease associated CD8+ lymphocyte biomarkers in nervous system inflammation and rheumatic diseases.
5. MHC I allelic variation and expression in nervous system inflammation and rheumatic diseases (including myositis).
6. Therapeutic approaches to modulate autoimmune inflammation via CD8+ lymphocytes.

Dr. Pizzolla receives financial support from Roche-Genentech. The other Topic Editors declare no competing interests with regards to the Research Topic theme.


Keywords: Adaptive immunity, Cytotoxic lymphocyte, CD8+ lymphocyte, CNS inflammation, rheumatic disease


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The best-known disease-associated genetic factors in autoimmune diseases are mapped to the MHC II locus, which has prompted the scientific community to examine the CD4+ T helper cells in great detail. Interestingly, many autoimmune diseases (such as many rheumatic diseases and multiple sclerosis) are also linked to classical and non-classical MHC I alleles, highlighting the importance of CD8+ lymphocytes in the induction, regulation and progression of autoimmune inflammation. MHC I play an important role in controlling viral infections, which are well known risk factors for many autoimmune diseases (e.g. Epstein-Barr virus in multiple sclerosis and rheumatic disease). Furthermore, it is also known that CD8+ lymphocytes are overrepresented in the acute multiple sclerosis brain lesions as well as in the synovial tissue isolated from patients with autoimmune arthritis. Results from recent studies utilizing modern high-through put methods have further strengthened the concept of CD8+ lymphocytes as important regulators and effectors of autoimmune inflammation.

This Research Topic is focused on the role of CD8+ cytotoxic lymphocytes in chronic, non-infectious inflammation and will provide a comprehensive overview of these timely issues with a particular emphasis on neuroinflammatory and rheumatic diseases. We welcome submissions of Original Research, Perspective, Clinical Trial, Case Report and Review articles on human and/or animal studies that cover, but are not limited to, the following topics:

1. Mechanisms of CD8+ lymphocyte mediated disease progression and/or regulation in central and peripheral nervous system inflammation.
2. CD8+ lymphocytes as inflammation modulators in rheumatic diseases (including myositis).
3. Interaction of CD8+ lymphocytes and class I MHC molecule mediated antigen presentation.
4. CD8+ lymphocyte immune repertoires and disease associated CD8+ lymphocyte biomarkers in nervous system inflammation and rheumatic diseases.
5. MHC I allelic variation and expression in nervous system inflammation and rheumatic diseases (including myositis).
6. Therapeutic approaches to modulate autoimmune inflammation via CD8+ lymphocytes.

Dr. Pizzolla receives financial support from Roche-Genentech. The other Topic Editors declare no competing interests with regards to the Research Topic theme.


Keywords: Adaptive immunity, Cytotoxic lymphocyte, CD8+ lymphocyte, CNS inflammation, rheumatic disease


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 July 2020 Abstract
31 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 July 2020 Abstract
31 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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