About this Research Topic
Brain delivery of drugs is strongly hampered by ability of crossing the blood-brain barrier and/or inefficient brain exposure to potentially active molecules. Novel strategies have been investigated over the last 10 years, but there still remains an alarming absence of effective approaches. A deeper analysis of these strategies should be done, from analyzing basic neuroscience, to applied neuropathology, and finally converge to an evaluation of state-of-the-art approaches, namely loco-regional and systemic strategies to overcome the blood-brain barrier.
The scope of this Research Topic is to provide a comprehensive overview of different aspects of brain delivery, with focus on neurobiology, neurodegenerative disorders, brain tumors and innovative nanomedicine-mediated approaches. Original Research as well as Review Articles of the last 10 years in the different fields are welcome. Preliminary research could also be accepted.
The aim of this Research Topic is dedicated to brain diseases and innovative technologies for new therapeutic chances. The following sub-themes are encouraged to submit:
• Basic neuroscience evidences of the blood-brain barrier and brain diseases with highlight on in-vivo and in-vitro models available;
• Brain diseases with special focus on neurodegenerative disorders (such as Huntington's Disease), the limits and challenges of current and future therapies;
• Overview of brain delivery approaches;
• Overview of loco-regional brain delivery and focus on Glioblastoma approaches;
• Overview on targeted nano-medicines for brain delivery by systemic administration.
Keywords: Nanomedicines, brain, blood-brain barrier, central nervous system
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.