About this Research Topic
Exosomes are small double membrane vesicles with a typical diameter of 50-120 nm and generated via formation of multivesicular bodies virtually in every cell type is mediated by changes in intracellular [Ca2+]. Being considered a part of cells waste management system for decades, our understanding of exosome function in function of central nervous system has been transformed in recent years. For years, intercellular communication has been hypothesized to be solely regulated by cell-to-cell contacts and release of soluble molecules into the extracellular space. Recent discoveries have shown that exosomes are key vehicles behind transfer of numerous proteins, lipids, RNAs and microRNAs between cells. Recent studies have shown the importance of exosomes in multiple aspects of cancer biology, modulation of the immune response, and neuronal protection, regeneration and development. Thereby providing new widely unexplored area of brain physiology in health and disease with big therapeutic potential.
Despite growing evidence for importance of exosomes for normal brain physiology, there is still significant controversy on how and where exosomes exert their functions and how exosomes can be used in battling brain diseases. Hence, at the moment there is no unified concept for exosome roles in the central nervous system. The main goal of this Research Topic is to explore diverse functions of exosomes in CNS and provide a hub where recent findings on exosomes will be summarized and future roadmap for exosome research will be set.
We welcome Original Research and Review articles from both academic and industry leaders in exosomes field, falling under brain health and disease conditions. Particularly, we encourage contributions on the following points:
a) Exosomes in glia physiology;
b) Exosomes and neuronal function;
c) Body-derived exosomes in brain physiology.
a) Exosomes in brain oncology;
b) Exosomes in neurodegeneration;
c) Exosomes as therapeutic modality.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.