Research Topic

Therapeutic Opportunities and Innovative Biomarkers in Tumor Microenvironment

About this Research Topic

Tumor microenvironment (TME), known as a battlefield between the cancer cells and host immune system, plays an indispensable role in cancer progression and metastasis. Studies focusing on TME have significantly improved our understanding of cancer biology, helped identify diagnostic or prognostic biomarkers, and provided novel anticancer targets. However, this research field is relatively new and thus understudied. For example, de novo or acquired resistance to drugs targeting TME is frequently observed in many types of cancer, and unfortunately not many clinically useful TME-based biomarkers have been developed to help stratify patients who may benefit from the immunotherapy. Therefore, it is urgent to deepen our knowledge of how TME works and to brainstorm ideas of effectively targeting TME for cancer therapy.

This Research Topic welcomes Original Research and Review Articles that focus on the following research areas in TME:

(1) Novel strategies for blocking tumor-promoting effects of TME or synergizing with currently available agents that modulate TME.
(2) Innovative TME biomarkers for cancer diagnosis or prognosis, or for predicting responses of cancer cells to certain TME-targeting treatment.
(3) Advanced methodologies or tools, such as three-dimensional organoids and multi-omics approaches, to comprehensively investigate the roles of TME in cancer progression and metastasis.


Keywords: anticancer therapies, biomarkers, cancer disparities, diagnosis, methylation, methodology, prognosis, tumor microenvironment


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Tumor microenvironment (TME), known as a battlefield between the cancer cells and host immune system, plays an indispensable role in cancer progression and metastasis. Studies focusing on TME have significantly improved our understanding of cancer biology, helped identify diagnostic or prognostic biomarkers, and provided novel anticancer targets. However, this research field is relatively new and thus understudied. For example, de novo or acquired resistance to drugs targeting TME is frequently observed in many types of cancer, and unfortunately not many clinically useful TME-based biomarkers have been developed to help stratify patients who may benefit from the immunotherapy. Therefore, it is urgent to deepen our knowledge of how TME works and to brainstorm ideas of effectively targeting TME for cancer therapy.

This Research Topic welcomes Original Research and Review Articles that focus on the following research areas in TME:

(1) Novel strategies for blocking tumor-promoting effects of TME or synergizing with currently available agents that modulate TME.
(2) Innovative TME biomarkers for cancer diagnosis or prognosis, or for predicting responses of cancer cells to certain TME-targeting treatment.
(3) Advanced methodologies or tools, such as three-dimensional organoids and multi-omics approaches, to comprehensively investigate the roles of TME in cancer progression and metastasis.


Keywords: anticancer therapies, biomarkers, cancer disparities, diagnosis, methylation, methodology, prognosis, tumor microenvironment


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

15 June 2020 Abstract
13 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

15 June 2020 Abstract
13 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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