Research Topic

Development of New Synthetic and Semisynthetic Marine-Derived Scaffolds as Drug Leads and Pharmaceuticals

About this Research Topic

Marine organisms produce highly active compounds as a defensive mechanism in their watery environment. Most of these compounds are highly active and selective against several biological targets. A critical issue in the drug development of marine-derived molecules and often a bottleneck is the constant availability of enough amounts of producing organisms and compounds without harming the marine environment. Enzymatic synthesis or modification or chemical synthesis/semi synthesis/modification are among the tools that can overcome the supply issue of a desired compound. Also, the development of new analogues through semisynthetic derivatization or total synthesis could solve the supply issue of such compounds or provide new and more active and/or less toxic analogues for the development of more effective drugs.

This Research Topic will cover all scopes of synthesis and semisynthesis of marine-derived molecules and their SAR studies towards the development of new and active marine-derived scaffolds, drug leads and pharmaceuticals.

This Research Topic will cover all scopes of enzymatic synthesis or modification or chemical synthesis/semi synthesis/modification of marine-derived bioactive molecules and SAR studies. We invite submissions of Original Research and Review articles on themes including but not limited to:

• Enzymatic synthesis of marine-derived compounds
• Derivatization and semisynthesis of bioactive marine molecules
• Total synthesis of marine bioactive compounds
• SAR studies of different synthetic/semisynthetic marine-derived analogues.


Keywords: bioactive marine compounds, enzymatic synthesis, chemical derivatization, semisynthesis and derivatization, total synthesis, SAR studies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Marine organisms produce highly active compounds as a defensive mechanism in their watery environment. Most of these compounds are highly active and selective against several biological targets. A critical issue in the drug development of marine-derived molecules and often a bottleneck is the constant availability of enough amounts of producing organisms and compounds without harming the marine environment. Enzymatic synthesis or modification or chemical synthesis/semi synthesis/modification are among the tools that can overcome the supply issue of a desired compound. Also, the development of new analogues through semisynthetic derivatization or total synthesis could solve the supply issue of such compounds or provide new and more active and/or less toxic analogues for the development of more effective drugs.

This Research Topic will cover all scopes of synthesis and semisynthesis of marine-derived molecules and their SAR studies towards the development of new and active marine-derived scaffolds, drug leads and pharmaceuticals.

This Research Topic will cover all scopes of enzymatic synthesis or modification or chemical synthesis/semi synthesis/modification of marine-derived bioactive molecules and SAR studies. We invite submissions of Original Research and Review articles on themes including but not limited to:

• Enzymatic synthesis of marine-derived compounds
• Derivatization and semisynthesis of bioactive marine molecules
• Total synthesis of marine bioactive compounds
• SAR studies of different synthetic/semisynthetic marine-derived analogues.


Keywords: bioactive marine compounds, enzymatic synthesis, chemical derivatization, semisynthesis and derivatization, total synthesis, SAR studies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

03 July 2020 Abstract
30 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

03 July 2020 Abstract
30 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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