About this Research Topic
The complex dynamic interaction between the oral microbiome and the host immune system plays a crucial role in the maintenance of oral health. The overgrowth of bacterial biofilm activates the host immune response aiming to eliminate invading bacteria and recover healthy homeostasis. Whereas the recognition and elimination of pathogens are mainly achieved by specialized immune cells of both the innate and the adaptive immune system, the role of non-immune cells in the immune response is less appreciated. Mesenchymal stem/stromal cells (MSCs) are specialized cells, which fulfill certain criteria like the expression of specific surface marker patterns and limited multilineage differentiation ability. MSC-like cells were found in different postnatal tissues, including numerous dental tissues such as the dental pulp, human exfoliated deciduous teeth, the periodontal ligament, the apical papilla, the dental follicles, and the gingival tissue.
There are several possibilities for how tissue-specific MSCs might contribute to the host immune response. First, these cells express various pattern recognition receptors and produce various inflammatory mediators in response to stimulation with various pathogenic stimuli. Second, these cells possess immunomodulatory abilities and influence the functional activity of specialized immune cells, like neutrophils, monocytes/macrophages, and lymphocytes. The immunomodulation by dental MSCs and the activity of immune cells are tightly regulated by reciprocal mechanisms, including the numerous inflammatory mediators. Third, MSCs might affect the integrity of the epithelial layer, which is a mechanical barrier hindering the invasion of most microorganisms into the body. However, the exact role of dental MSCs in the healthy and pathological conditions still needs to be understood.
This Research Topic focuses on the contribution of dental MSCs into host immune response and their potential role in the different pathological processes like periodontal disease, pulpitis, and oral squamous cell carcinoma. Authors are encouraged to submit in vitro, animal, and clinical studies, as well as review papers within the scope of this topic that may include but, are not limited to:
- Expression and function of different pattern recognition receptors in dental MSCs
- Immunomodulatory effects of dental MSCs
- MSCs response to oral biofilms
- MSCs based strategies in the therapy of oral diseases
Keywords: Dental Mesenchymal Stem/Stromal Cells, Oral Pathogens, Host-Pathogen Interaction, Innate Immunity, Immunomodulation
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