About this Research Topic
The Tumor Microenvironment (TME) is a complex system that interacts with the tumor and its surroundings. A lack of relevant translational methods to explore the complex relationships within the TME has hindered in-depth research on this topic. For example, the monitoring of tumor drug delivery in vivo is a huge challenge due to the heterogeneity and complexity of the tumor microenvironment. Recently, the TME has drawn more attention in attempts to overcome current drug resistance and cancer recurrence by systematically understanding cancer and its microenvironment, through microfluidics. Microfluidic models will help us better understand the complex biology of the TME.
Cancer organoids in vitro serve to replicate specific aspects of tumors, and are an emerging technology that is enabling rapid drug discovery. The techniques used to form these organoids, however, are highly limited in terms of the structures that can be created; the ability to define and reflect the heterogeneity of these organ-analogs will make tumor models an even more powerful tool for biomedical science. In this research topic, we will like to look at the following issues:
• The technological advancements in microfluidics that confers greater translational relevance to in vitro tumor models
• The impact of tumor microenvironment on establishing effective tumor models
• Novel advances in tumor microenvironmental studies using integrated microfluidic systems
• Approaches to identify biochemical signatures of TME for the development of sensitive and accurate microfluidic diagnostic systems.
The current Research Topic covers both cell-based and patient-derived studies on novel tumor model design based on the microenvironment factors, impact, and outcome of various tumor microfluidic models. These include but are not limited to the following themes:
• Novel design and study of tumor microfluidic models
• In vitro cell-based and patient-derived tumor models
• Incorporation of various aspects of the tumor microenvironment, such as hypoxia, tumor-associated cells, etc.
• Various applications and impact of in vitro tumor models on cancer diagnosis, monitoring, treatment, etc.
• Use of systems biology approaches (genomics, transcriptomics, proteomics, and metabolomics) to unravel the complexity in the tumor microenvironment
Keywords: Tumor Microenvironment, Heterogeneity, Microfluidic models, cancer diagnosis, systems biology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.