About this Research Topic
This Research Topic highlights the need to find more meaningful breast cancer biomarkers and druggable targets based on originality, importance and timeliness. Although the 5-year overall survival rate of early breast cancer is over 90%, many patients still undergo recurrence, metastasis and drug resistance even after standard treatment in clinical practice. Besides, drawing from the great success that we have achieved by treating breast cancer based on molecular subtypes (luminal, HER2-enriched and triple-negative), increasingly accurate subtyping methods are still underway, such as classical VICC and FUSCCTNBC classification system of triple-negative BC.
We welcome Original Research, leading-edge Reviews and Clinical Trials related but not limited to the aspects below:
• Identification and validation of clinically significant novel biomarkers to predict therapy response and prognosis of breast cancer;
• Data analysis and validation identifying novel features of breast cancer to better guide future treatment;
• Underlying mechanisms of recurrence or metastasis of breast cancer;
• Identification of druggable targets in breast cancerand classified subgroups;
• Preclinical research translating molecular targets into clinical practice;
• Clinical trials illustrating response to therapy in breast cancer;
• Population-based studies of clinical features of breast cancer.
To be considered for publication, studies must demonstrate the applicability of anticancer modalities on a minimum of two well-authenticated cancer cell lines. Studies consisting solely of in silico investigation without experimental or in situ validation to support conclusions are not in scope of this Research Topic.
Keywords: Breast Cancer, Biomarker, Therapeutic Target, Predictive, Prognosis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.