About this Research Topic
Gut microbes include more than 800 species, which constitute the gut microbiome as a whole, and these microbes contribute to the digestion of food, provide necessary nutrition and prevent the invasion of pathogens. In order to maintain this beneficial relationship, the intestinal mucosal system may play a regulatory role by inducing immune signaling pathways. However, when this harmonious environment is disturbed, thechange of intestinal microbiota canenhance the resistance to pathogenic bacteria or promote their infection. Moreover, accumulating evidence highlights a critical role for bacterial metabolites in the intestinal immune process. Forexample, the bacterial fermentation product of short-chain fatty acid acetic acid enhances the intestinal IgA responses mediated by " metabolite-sensing " GPR43;butyrate induces monocytes to differentiate into macrophages through histone deacetylase 3 inhibition, which may drive macrophage function to develop towards antibacterial defense.Lipopolysaccharide increases intestinal epithelial cell apoptosis and stimulates the innate immune system to induce intestinal glucocorticoid synthesis in a TNF-dependent manner. Bacterial metabolites stimulate the “gut-brain-axis” to alter neural circuits or higher-order brain functions and behaviors. Of course, there are some known or unknown bacterial metabolites that need us to explore whether they are involved in intestinal immune regulation and their specific mechanisms.The interaction between host intestinal immune system and intestinal bacteria or bacterial metabolites is critical to the integrity and function of the intestine, but how these interactions regulate the response of immune cells in the intestine is still an important gap in the field.
This Research Topic aims to highlight mechanisms of bacteria or bacterial metabolites involved in gut immunity. The content will include the interaction between bacteria and bacterial metabolites with gut immunity in cell or animal models.
Original Research and Review articles are welcome covering the following themes:
• The role of commensal and pathogenic bacteria or bacterial metabolites on the gut health and on signal transmission in gut-brain-axis
• Molecular mechanisms underlying the influence of commensal and pathogenic bacteria on the gut immunity or homeostasis
• Molecular mechanisms underlying the influence of bacterial metabolites on the gut immunity
• Influencing intestinal immune status by affecting commensal and pathogenic bacteria or bacterial metabolites
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