About this Research Topic
Both epigenetics and metabolism researches are recently accelerated rapidly, generating justified excitement and hope in cancer research. Cancer cells inherit metabolic reprogramming and emerge metabolic plasticity that admits them to regulate malignant phenotypes and tumorigenesis within the tumor microenvironment. Recent finding has definitized contact between metabolites or intermediates and protein post-translational modifications, whereas metabolites or intermediates are substrates of enzymes as well as histone and non-histone proteins, which add or remove different modifications such as acetylation, phosphorylation, methylation, ubiquitination, glycosylation, crotonylation and lactylation, implicating them in many biological functions through the regulation of chromatin remodeling, metabolism, organelles and immunology via transcriptional control. Moreover, the impact of metabolites or intermediates in RNA modification and splicing is emerging as new research areas. A better understanding of how metabolic changes in cancer affect gene regulation and or organelles can reveal new weaknesses that target treatment. Therefore, it is urgent to deepen our knowledge of how metabolic reprogramming works via chromatin modification and to brainstorm methods of effectively targeting metabolic plasticity for cancer therapy.
This Research Topic aims to provide a fundamental statement of the current situations of our understanding on the molecular mechanisms involved in all processes of metabolism and chromatin modification in cancer.
We welcome the submission of Original Research, Methods, Review and Mini-Review articles that cover, but are not limited to the following topics:
· Epigenetic regulation and intermediates in cancer
· RNA modification and metabolism in cancer
· RNA splicing in cancer
· Interplay of metabolism and gene expression in cancer
· The role of organelles in metabolism and immunity
· The role of metabolites in tumor microenvironment
· New models for the interplay between metabolism and chromatin modification
· New technologies for metabolism and chromatin modification
Keywords: Metabolism, Metabolites, Epigenetics, tumor microenvironment, Immunity
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