About this Research Topic
Graphene oxide is the most explored 2D material in the last decade for a number of biomedical applications. It has attracted considerable attention in cancer therapy as a drug carrier because of its huge potential to overcome the problems of existing chemotherapeutic agents.
Graphene oxide has the ability to not only to deliver pharmacologically active agents at a controlled rate, site, and release time in vivo, but also to increase the solubility and alter the pharmacokinetics of the antineoplastic agents thus enhancing their therapeutic efficacy. Graphene oxide was found to deliver drugs into tumor cells with minimum drug leakage into normal cells thus greatly diminished side effect profiles. Conjugation of graphene oxide with ligands of cancer-specific tumor biomarkers leads to effective targeted drug delivery to cancer cells and cancer attenuation. These properties of graphene oxide enable:
• drug combinations formerly inhibited by toxicity limits
• new classes of drug delivery (for example, siRNA)
• provide cell-specific targeting within a tumor
The adaptability and variability of different cancers require a multimodal approach for the development of the most effective therapy for patients, as well as for the opportunity to advance cancer research. The potential to perform multiple functions using one agent is attractive as an approach for the integration of molecular cancer therapeutics with nanomaterials-based drug-delivery systems.
In addition to the aforementioned properties of graphene oxide, its strong near-infrared absorption (NIR) and high photothermal conversion efficiency can be used as a photo-adsorbing agent in photothermal (PTT) and photodynamic (PDT) cancer therapy. All these features and characteristics unambiguously demonstrate the ability of graphene oxide to perform multiple functions which is a prerequisite for its use in the design of novel effective strategies for treating cancer.
This Research Topic is aimed at bringing together the current state-of-the-art research efforts in the synthesis, characterization, and the sea of recent applications of new formulations of graphene oxide in the field of cancer therapy. It invites innovative contributions in terms of research articles, reviews, and communications from around the globe.
Potential topics include, but are not limited to:
• Graphene oxide-based technologies for chemo-, gene-, photodynamic or photothermal therapy or combination of these therapeutic approaches
• Effects of graphene oxide-based formulations in vitro on cancer cells and in vivo on animal models of cancer
• Future perspectives and potential challenges of graphene oxide-based cancer technologies to address transition into the clinic
Keywords: GO nanoparticles, 2-D materials, Graphene Oxide, Drug delivery systems, Tumor cells
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