Research Topic

Mechanisms of Toxicity of Engineered Nanomaterials

About this Research Topic

Nanotoxicology is an interdisciplinary research field spanning from material characterization to hazard and exposure assessment and, ultimately, risk assessment and risk management. The aim is to clarify the potential hazards of nanomaterials to the environment and human health. Nanotoxicology may also provide insights into biological mechanisms by elucidating the interactions of man-made nanomaterials with biological systems, thus bridging to nanomedicine.

Nanotoxicology has made considerable progress in the last ten to fifteen years and studies are beginning to shed light on the mechanisms of (eco)toxicity of various types of nanomaterials. However, most studies are still rooted in the same mechanistic paradigm(s) such as the oxidative stress paradigm, and mainly address the same or very similar endpoints including cytotoxicity, genotoxicity, and so on. These are important aspects, but there is a need for a deeper understanding of the molecular mechanisms that are activated or perturbed by nano-scale materials. Recent advances in terms of genome-wide omics technologies may help to shed light on the mechanisms of toxicity of nanomaterials if coupled to meaningful validation experiments. Close attention must also be paid to the relevance of the model systems applied.

This Research Topic is mainly focused on, but not limited to, the following subtopics:
• Studies on molecular mechanisms of nanomaterials using in vitro or in vivo models
• Systems biology studies in which omics technologies are applied to nanomaterials
• Studies using advanced/alternative model systems to address nanomaterial toxicity
• Computational (modeling) studies including, for instance, molecular dynamics work
• Studies that go beyond crude measurements of live-dead read-outs; low-dose studies
• Studies on nanomaterials that can be exploited in nanomedicine (i.e., “nanologicals”).

We welcome submissions of article types including Original Research, Hypothesis & Theory, Reviews and Perspectives (please see the details about the article types available here).

We aim to highlight excellent research from different parts of the world and we look forward to your valuable contribution.


Keywords: Nanomaterials, Nanotoxicology, Molecular mechanisms, Molecular dynamics, Nanomedicine


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Nanotoxicology is an interdisciplinary research field spanning from material characterization to hazard and exposure assessment and, ultimately, risk assessment and risk management. The aim is to clarify the potential hazards of nanomaterials to the environment and human health. Nanotoxicology may also provide insights into biological mechanisms by elucidating the interactions of man-made nanomaterials with biological systems, thus bridging to nanomedicine.

Nanotoxicology has made considerable progress in the last ten to fifteen years and studies are beginning to shed light on the mechanisms of (eco)toxicity of various types of nanomaterials. However, most studies are still rooted in the same mechanistic paradigm(s) such as the oxidative stress paradigm, and mainly address the same or very similar endpoints including cytotoxicity, genotoxicity, and so on. These are important aspects, but there is a need for a deeper understanding of the molecular mechanisms that are activated or perturbed by nano-scale materials. Recent advances in terms of genome-wide omics technologies may help to shed light on the mechanisms of toxicity of nanomaterials if coupled to meaningful validation experiments. Close attention must also be paid to the relevance of the model systems applied.

This Research Topic is mainly focused on, but not limited to, the following subtopics:
• Studies on molecular mechanisms of nanomaterials using in vitro or in vivo models
• Systems biology studies in which omics technologies are applied to nanomaterials
• Studies using advanced/alternative model systems to address nanomaterial toxicity
• Computational (modeling) studies including, for instance, molecular dynamics work
• Studies that go beyond crude measurements of live-dead read-outs; low-dose studies
• Studies on nanomaterials that can be exploited in nanomedicine (i.e., “nanologicals”).

We welcome submissions of article types including Original Research, Hypothesis & Theory, Reviews and Perspectives (please see the details about the article types available here).

We aim to highlight excellent research from different parts of the world and we look forward to your valuable contribution.


Keywords: Nanomaterials, Nanotoxicology, Molecular mechanisms, Molecular dynamics, Nanomedicine


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

10 July 2020 Abstract
10 November 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

10 July 2020 Abstract
10 November 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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