About this Research Topic
Abnormal epigenetic modifications in DNA, RNA and histones have been shown to orchestrate genetic alterations in cancer development, which effectively influence the malignancy of tumors. To date, epigenetic regulation has been proved to involve cell growth and differentiation, cell cycle control, DNA repair, angiogenesis, migration, and evasion of host immune surveillance pathways in tumors. Previous studies have laid the foundation for novel therapeutic strategies that target epigenetic regulation in malignant cancers.
The tumor microenvironment describes the non-cancerous cells present in the tumor as well as the proteins produced by all of the cells that support the growth and metastasis of the cancer cells. The overall biochemical processes that occur in tumors to provide energy for cellular function and growth are classified as tumor metabolism. Various studies have shown that tumor microenvironment and metabolism contribute to the progression of cancers.
Current studies suggest that abnormal epigenetic modifications can absolutely affect the regulation of the tumor microenvironment and metabolism in various cancers. The use of modern genomic, proteomic, metabolomics, and functional analytical techniques has contributed to identifying novel genes and signalling networks involved in epigenetic modifications in the tumor microenvironment and metabolism. Moreover, the use of high-throughput techniques in combination with bioinformatics and systems biology approaches has aided the interrogation of clinical samples.
Despite much progress having been made in understanding the tumor microenvironment and metabolism, the role of epigenetic modifications remains largely unknown. Here we plan to solicit further research into the mechanisms of epigenetic regulation in the tumor microenvironment and metabolism in human cancers, and corresponding strategies which will help achieve long-lasting disease control and provide survival benefits to patients with advanced cancer.
The current Research Topic of Frontiers in Molecular Biosciences and Frontiers in Oncology focuses on publishing Original Research, Methods, Review, and Opinion articles focusing on:
• Elucidating mechanisms of proliferation, metastasis or drug resistance in malignant cancers by epigenetic regulation, including but not limited to tumor microenvironment and metabolism signaling pathways
• Promising drug delivery systems for epigenetic regulation in the tumor microenvironment and metabolism regulators which can enhance the therapeutic effect to various tumors
• Potential drugs (small molecule compounds, peptide, etc) that target epigenetic regulation in tumor microenvironment and metabolism
• Epigenetic regulation biomarkers of tumor microenvironment and metabolism in cancer patients, including but not limited in RNA modifications and non-coding RNAs
Guidelines for the article of submission:
- Authors must stick to the set guidelines for ethical practices by the Frontiers journals.
- The main content of the article must have certain innovation and research significance.
Keywords: Epigenetic regulation, tumor microenvironment, cancer metabolism, RNA modification, non-coding RNA
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.