About this Research Topic
Over the years, several materials have been produced at the nanoscopic level and engineered for efficient drug delivery, such as metallic, organic and natural based products. In recent years, innovative nanotechnology-based drug delivery techniques have been developed for the treatment and diagnosis of a variety of diseases, such as cancer, diabetes, atherosclerosis, myocardial ischemia, asthma, and neurodegenerative disorders . Efficient drug delivery plays a crucial role in disease treatment and remains an important challenge in medicine. In particular, the delivery of drugs to a target site frequently involves crossing biological barriers. Recent advances in the field of microfabrication have offered the possibility to develop systems for drug uptake through biological barriers.
Nanocarrier based drug-delivery could ameliorate pharmacokinetics, modifying the therapeutic index and accomplishing the desired pharmacological response in the target tissue. The physicochemical properties (shape, porosity, size, surface chemistry, elasticity, and others) of these nanocarriers affect their biological behavior, which, in the presence of biological barriers in vivo, could significantly modify the therapeutic index of their cargo and address the desired outcome. Particular attention in developing drug nanocarriers should be given to safety, cellular uptake and permeation of biological barriers. In fact, in order to develop nanocarrier drug delivery systems, safety should be carefully evaluated in order to avoid side effects due to the physico-chemical nature of the carriers. The degree and nature of the impediment to overpass the barriers as well as the potential approaches to overcoming it, depend on the the drug, the tissue, and several other factors. Improving our technology and knowledge concerning these issues in a variety of organs may represent a promising solution for efficient and safe drug deliveryand have a significant clinical impact.
A main challenge in the drug delivery field is improving the transport of therapeutics across biological barriers, including the blood brain barrier (BBB), nasal mucosa, the small intestine, the mouth mucosa and skin. These barriers are designed by nature to keep external material out, and only allow small molecules with specific characteristics to cross, e.g. by receptor regulated transcytosis. Thus, it is important to develop engineered nanocarriers for improved drug uptake through biological barriers. However, in developing these nanocarriers, it will be important to keep focus on simplicity, patient-friendliness and cost-effectiveness.
This Research Topic seeks innovative manuscripts on engineered nanocarriers for drug permeation through biological barriers, reporting advances in engineering nanocarriers allowing, possibly, the translation into clinical practice. Authors are welcome to submit Original Research and Review articles.
• Properties and synthesis of biomaterials for successful drug uptake through biological barriers
• Novel engineered nanocarriers approaches for dermal drug delivery
• Novel engineered nanocarriers approaches for drug delivery in cancer therapy (across biological barriers)
• Novel engineered nanocarriers approaches for BBB drug delivery
• Innovative technologies in drug delivery systems such as 3-D printed devices for drug uptake through biological barriers
Important Note: All submissions/contributions to this Research Topic must be in line with the scope of the journal/section they are submitted to. While authors are encouraged to draw from other disciplines to enrich their papers where relevant, they must ensure papers fall within the scope of the journal/section, as expressed in its mission statement.
Dr. Annamaria Cimini holds patents related to nanomaterials and nanocarriers. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Drug Delivery, Nanotechnology, Nanocarriers, Targeting, Nanomedicine, Nanodevice, Biological Barriers
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.