Research Topic

Phenotyping Osteoarthritis and its Symptoms: From Observation to Intervention

About this Research Topic

Osteoarthritis (OA) is the most prevalent form of arthritis worldwide. It is a chronic and painful disease of the synovial joint, and a leading cause of disability. Contrary to inflammatory joint diseases, no disease-modifying drugs are currently available for treating OA. The standard approach includes agents for control of pain and inflammation (non-steroidal anti-inflammatory drugs, analgesics including opioids and intraarticular corticosteroids) and joint replacement in end-stage disease.

OA and its symptoms (i.e. pain) are heterogeneous and characterised by a complex and multifactorial nature. Identification of therapies that improve quality of life in patients with OA or prevent structural progression of the disease has been negatively affected by marked clinical heterogeneity in the rate of progression, discordance between symptoms and structural changes and symptom fluctuation over time. With increasing understanding of OA risk factors and pathogenesis, OA is not only considered a disease of cartilage but consists of different subgroups/phenotypes.

This Research Topic aims to tackle the urgent unmet need for OA management and treatment by identifying clinical subgroups characterised by different phenotypes. A such, this Research Topic welcomes:

• Review and meta-analysis articles that cover emerging insights into the identification of OA and pain phenotypes;
• Original research articles that identify important differential characteristics (baseline clinical characteristics, biologic aspects including measures of metabolic activity, distinctive baseline structural and functional characteristics) associated with individual variation in long term prognosis and treatment outcomes;
• Secondary data analysis and individual patient data (IPD) meta-analysis in OA trials by looking at the efficacy of proposed treatments in identified patient sub-groups of patients with OA


Keywords: Osteoarthritis, Pain, Phenotypes, Cohort study, Clinical trial


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Osteoarthritis (OA) is the most prevalent form of arthritis worldwide. It is a chronic and painful disease of the synovial joint, and a leading cause of disability. Contrary to inflammatory joint diseases, no disease-modifying drugs are currently available for treating OA. The standard approach includes agents for control of pain and inflammation (non-steroidal anti-inflammatory drugs, analgesics including opioids and intraarticular corticosteroids) and joint replacement in end-stage disease.

OA and its symptoms (i.e. pain) are heterogeneous and characterised by a complex and multifactorial nature. Identification of therapies that improve quality of life in patients with OA or prevent structural progression of the disease has been negatively affected by marked clinical heterogeneity in the rate of progression, discordance between symptoms and structural changes and symptom fluctuation over time. With increasing understanding of OA risk factors and pathogenesis, OA is not only considered a disease of cartilage but consists of different subgroups/phenotypes.

This Research Topic aims to tackle the urgent unmet need for OA management and treatment by identifying clinical subgroups characterised by different phenotypes. A such, this Research Topic welcomes:

• Review and meta-analysis articles that cover emerging insights into the identification of OA and pain phenotypes;
• Original research articles that identify important differential characteristics (baseline clinical characteristics, biologic aspects including measures of metabolic activity, distinctive baseline structural and functional characteristics) associated with individual variation in long term prognosis and treatment outcomes;
• Secondary data analysis and individual patient data (IPD) meta-analysis in OA trials by looking at the efficacy of proposed treatments in identified patient sub-groups of patients with OA


Keywords: Osteoarthritis, Pain, Phenotypes, Cohort study, Clinical trial


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

20 July 2020 Abstract
17 November 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

20 July 2020 Abstract
17 November 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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