About this Research Topic
Other emerging genetic methods, such as Mendelian randomization and colocalization approaches, provide a rapid and cost-effective approach to inform the development of biomarkers for disease diagnosis and help prioritize drug targets for disease treatment. Recent studies have also demonstrated the value of proteome-wide and tissue-specific transcriptome-wide studies to promote the development of disciplined pipelines for causal inference and early therapeutic Research and Development for complex diseases. During the current COVID-19 pandemic, the enormous volume of genetic data also provides opportunities for a deeper understanding of SARS-CoV-2 infection in transmission and pathogenesis; disease susceptibility and severity; and mechanism of virus action and therapy. Thus, the growing availability of vast resources of omics data sets as proxies for disease pathogenesis combining with the recently developed methodologies will have very high clinical values for disease prevention and treatment.
In this Research Topic, we wish to highlight the role of integrating multi-omics data sets to support disease diagnosis and treatment from a translational perspective. Authors are encouraged to contribute Original Research, Review, and Mini-Review papers focusing on the promotion of translating genetic findings into a clinical setting. Sub-topics are included but not limited to the following:
1) Exploring the risk factors of disease incidence or progression;
2) Elucidating the molecular mediators underlying the disease pathogenesis;
3) Detecting the potential targets for disease diagnosis;
4) Prioritizing novel drug targets or repositioning existing drugs with efficacy and less adverse effects.
Keywords: multi-omics study, bioinformatics, translational perspective, disease pathogenesis, clinical implications
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.