About this Research Topic
It is a fundamental challenge to understand how brain function is related to its functional and structural organization, i.e., what shapes the neuronal activity patterns observed across scales that define cognitive and behavioral processes, as well as their breakdown in mental health disorders. The dynamics of neuronal networks strongly depends on intrinsic properties of the neuro-anatomical connectome and the functional relationships among neurons, and this goes beyond the connectivity matrix. In particular, the adaptation of the strengths of the synaptic connections through synaptic plasticity, the evolution of the functional connectivity in time, the inevitable time-delays resulting from both neurophysiological time constants and finite propagation velocity, noise, and inherent inhomogeneities play key roles in the emergent behavior of neuronal systems across spatial and temporal scales. A detailed characterization of these effects on the collective dynamics of neuronal networks may thus provide the means for studying the link between functional and structural connectivity and brain function.
This Research Topic focuses on the structure-function relationship in neuronal networks at different temporal and spatial scales. The latter can range from fast-spiking and bursting dynamics of individual neurons, mean collective activity of neuronal populations to slow and ultra-slow fluctuations of neuronal and metabolic activity at the whole-brain scale. Special attention will be paid to the modeling of the neuronal plasticity (or adaptivity), impacts of time delays in coupling and intrinsic activity, and effects of noise or stochastic perturbations on individual and collective neuronal dynamics. The goal of this Research Topic is to collect a wide spectrum of theoretical, computational, and experimental articles, which introduce recent advances in the modeling and analysis of the interplay between the parameters that define the network structure and the repertoire of dynamical regimes of neuronal networks. The close comparison of theoretical/simulation results to empirical brain recordings may contribute to elucidate the observed phenomena from the perspective of complex networks and nonlinear dynamics. Such a collection might contribute to a better understanding of how the brain connectome structure can shape the neuronal activity in space and time, ultimately leading to cognition and behavior.
This Research Topic invites all contributions ranging from Original Research to Review and Opinion articles that address the emergence and properties of the dynamics of neuronal networks with emphasis on structure-function relationship. Studies focusing on the impact of connectivity, synaptic plasticity, and other forms of neuronal adaptation, time-delay, and noise on the microscopic, as well as on the mesoscopic dynamics of neuronal populations, are warmly welcome. Mathematical modeling accompanied by validation of the theoretical and simulation results against empirical brain recordings and experimental and data-driven studies can provide complementary approaches for evaluating the phenomena and the corresponding mechanisms of the neuronal dynamics and brain function. Topics considered to be in the scope of this Research Topic include, but are not limited to, the following:
• adaptive neuronal networks;
• neuronal networks with time-delays;
• noise-induced phenomena in neuronal dynamics;
• neuronal synchronization, clustering and pattern formation;
• activity patterns in complex heterogeneous neuronal networks;
• mesoscopic and macroscopic dynamical models for specific brain circuits and the whole-brain.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.