About this Research Topic
Mitochondrial physiology is modulated by many factors including lifestyle, diet, exercise, pathologies and infections. Mitochondrial dysfunction not only depends on the incapacity of mitochondria to perform the metabolic reactions involved in the production of energy as ATP. Mitochondrial dysfunction also regulates many cell responses affecting calcium homeostasis, cell signaling, oxidative damage, lipid synthesis and inflammatory response among others. Physiological mitochondrial activity depends on the regulation of mitochondrial biogenesis and the removal of damaged and ineffective structures. The balance between mitochondrial biogenesis and removal through mito/autophagy is key to avoid the accumulation of damaged structures. On the other hand, dynamics of mitochondrial structure to maintain the right organization depending on the specific needs of cells also needs a balanced control. Many bioactive compounds found in vegetables and other nutrients promote the removal of dysfunctional mitochondria and the biogenesis of new structures maintaining high capacity in pathological conditions such as diet and age-related diseases. Furthermore, many of these bioactive compounds also induce autophagy and the removal of mitochondrial and other structures avoiding accumulation of cell debris during aging.
Mitochondrial dysfunction is key in many metabolic-related diseases, many of them associated with aging. The induction of pathways that activate mitochondrial turnover and dynamics improves the progression of these diseases and is also key in prolongevity procedures and therapies.
Bioactive compounds found in nutrients induce mitochondrial dynamics and turnover activating the removal of damaged structures and inducing a more balanced mitochondrial activity. This Research Topic in Frontiers in Physiology focus on the effect of bioactive compounds in the physiology of mitochondria from mitochondrial activities to dynamics and turnover. The influence of these compounds can offer a new strategy to avoid mitochondrial dysfunction in many diseases and in aging.
This Research Topic offers the opportunity to revise the importance of bioactive compounds on mitochondrial physiology. Our main goal is to offer a collection of high quality papers including revisions and original papers that increase the knowledge about the effect of bioactive compounds in mitochondrial activity and maintenance and its putative role in the prevention and treatment of diseases in which mitochondrial dysfunction is key. The aspects we would like to uncover are:
• Bioactive compounds and mitochondrial dynamics.
• Age-related diseases and its treatment with bioactive compounds.
• Effect of bioactive compounds in energy maintenance during aging.
• Polyphenols and modulation of sirtuins in longevity
• Bioactive compounds-associated pathways in mitochondrial homeostasis
• Importance of mitochondria in chronic inflammation and its regulation by bioactive compounds.
• Mitochondria and inflammation: role of mito/autophagy and its regulation by nutrients.
• Nutrition and mitochondria: role of bioactive compounds.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.