Research Topic

The Fertilization Success from the Oocyte's Perspective

About this Research Topic

The entire fertilization process is extremely delicate and precise. Normal fertilization involves the fusion of a capacitated and reacted sperm with an ovulated oocyte. During this process, several sperm go through the zona pellucida and attempt to fuse with the oocyte's plasma membrane (oolema); however, ...

The entire fertilization process is extremely delicate and precise. Normal fertilization involves the fusion of a capacitated and reacted sperm with an ovulated oocyte. During this process, several sperm go through the zona pellucida and attempt to fuse with the oocyte's plasma membrane (oolema); however, only one sperm will be accepted by the oocyte in most mammals.

Contrary to a passive role, the oocyte has a very active participation in fertilization and preimplantatory embryo. First, the oocyte prepares both nucleus and cytoplasm during their maturation. During nuclear maturation, genetic material is carefully split in the meiotic division; thus, any error in this division will be fatal for the embyo life. During cytoplasmic maturation, all organelles are prepared for supporting fertilization and preimplantatory embryo development. For instance, mature and correctly located cortical granules are essential to avoid polyspermy during cortical reaction. Similarly, healthy mitochondria are indispensable for ensuring the cellular energy required for the oocyte and the embryo metabolism.

When all processes, known and unknown, involved in the oocyte biology occur normally, we define the female gamete as a “competent oocyte”, even in those species of mammals that have polyspermic fertilization such as pigs. Although today we have a lot of evidence to describe a good quality oocyte, the oocyte is still the “black box” of fertilization. An in-depth understanding of the mechanisms that define a competent oocyte is necessary considering that the oocyte is an essential part in the assisted reproductive techniques. In addition, finding molecular markers for oocyte selection is the main goal for assisted reproduction in humans and animals.

This Research Topic aims to develop an integrative view of all mechanisms involved in oocyte maturation and oocyte fertilization such as meiotic maturation of oocytes (meiosis), cytoplasmic oocyte maturation (organelles and receptors maturation), in vivo and in vitro oocyte maturation, cumulus cells, monospermic and polyspermic fertilization, oocyte activation (physiological or parthenogenetic), calcium signaling, cell polarity establishment, and cortical reaction.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

29 December 2020 Manuscript
15 March 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

29 December 2020 Manuscript
15 March 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..