About this Research Topic
Regular performed exercise is a powerful therapy against the development and progression of chronic and degenerative diseases such as type 2 diabetes, metabolic-associated fatty liver disease, cardiovascular disease, dementia and depression. All these well-acknowledged benefits of exercise go far beyond the known molecular adaptations of the working skeletal muscle. Thus, compounds released during exercise, in particular the secretome of the working muscle, gained huge attention because these exercise factors are signaling molecules in an organ cross-talk and mediators of health-promoting power of regular physical activity. In addition to skeletal muscle-derived myokines, exercise regulates the secretion of hepatokines from the liver and adipokines from the adipose tissue. The view on the overall composition of the exercise-induced secretome is incomplete without considering the dynamic changes of metabolites and lipids, which opens further perspectives for our understanding of the organ cross-talk during exercise. As an ultimate goal, our endogenous exercise factors are the template for the design of next-generation biological agents for the treatment of type 2 diabetes and other degenerative diseases.
To focus on the most recent knowledge in this fascinating topic we seek for original research and review articles that:
1. Describe the identification of novel exercise-regulated molecules (RNA, metabolites, lipids, proteins) in humans and their paracrine/endocrine function
2. Report on exercise factors which regulate brain function
3. Novel pharmaceutical drugs based on exercise factors
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