About this Research Topic
While the severity of both motor- and somatosensory disturbances is correlated with the amount of (myelinated) nerve fiber degeneration, consistent associations between the severity of neuropathic pain and (unmylinated) nerve fiber degeneration as measured by the density of cutaneous innervation have not been described. More generally, it is not obvious why some patients with neuropathy have neuropathic pain while others have not. Peripheral factors that may be involved in neuropathic pain include perineural inflammation, ischemia, ectopic firing of nociceptors, autonomic nerve dysfunction and nerve fiber degeneration. Concerning the latter, it is hypothesized that selective degeneration of subgroups of nociceptors may drive hyperalgesia and possibly that those subgroups may each convey specific information about pain. Thus, specific neuropathic pain qualities may be explained, like sensory-discriminative as opposed to affective/evaluative pain components.
The scope of this research topic contains the association between neuropathic pain and cutaneous innervation. This may include both experimental as well as clinical research and manuscripts using morphological as well as physiological or imaging techniques will be considered.
Keywords: Neuropathy, Pain, Cutaneous, Nociceptors, Peripheral
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