Research Topic

Novel mechanisms and innovative therapies in severe asthma

About this Research Topic

The asthma treatment guidelines have seen several new treatment options added in the past years, particularly for severe asthma- in which T2 biologicals form an important new class of add-on therapeutics. Despite these recent additions, only a sub-population of severe asthmatics are responsive to these new biologics and an unmet clinical need remains- particularly as it pertains to inflammation and re-modelling in severe asthma.

This collection will address potential new mechanisms and therapeutic targets for asthma in an explorative fashion, with the aim of paving the way for a new generation of pharmacological or non-pharmacological treatments. This will be achieved by highlighting mechanisms of inflammation and remodeling in asthma, and by reviewing key ongoing developments in asthma pharmacology.


Keywords: inflammation, asthma, remodeling, pharmacology, pathophysiology


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The asthma treatment guidelines have seen several new treatment options added in the past years, particularly for severe asthma- in which T2 biologicals form an important new class of add-on therapeutics. Despite these recent additions, only a sub-population of severe asthmatics are responsive to these new biologics and an unmet clinical need remains- particularly as it pertains to inflammation and re-modelling in severe asthma.

This collection will address potential new mechanisms and therapeutic targets for asthma in an explorative fashion, with the aim of paving the way for a new generation of pharmacological or non-pharmacological treatments. This will be achieved by highlighting mechanisms of inflammation and remodeling in asthma, and by reviewing key ongoing developments in asthma pharmacology.


Keywords: inflammation, asthma, remodeling, pharmacology, pathophysiology


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

07 November 2020 Abstract
07 March 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

07 November 2020 Abstract
07 March 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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