About this Research Topic
Bone is one of the most common metastatic sites for a wide range of solid tumors including lung, liver, breast, prostate, kidney, colorectal and thyroid malignancies. Generally, about 80% of bone metastases are osteolytic. The osteolytic destruction often induces skeletal-related events (SREs), such as local pain, hypercalcemia, pathologic fracture and even spinal cord compression, which may decrease the quality of life and reduce the overall survival (OS) of patients.
Despite the progress achieved in the past years, we are still trying to reach a better understanding of the mechanisms for bone metastasis of different malignancies. Clinical challenges need further attention as well, with the purposes of improving prediction (via prognostic clinical factors, for example), early diagnosis and treatment (via proper biomarkers and therapeutic targets, for example). There is also a need for well-designed studies with large samples and a long follow-up time to verify the effects of different therapeutic methods currently in use.
This Research Topic aims at reporting the recent progress in bone metastasis for solid tumors from mechanisms to clinical treatment.
We welcome submissions of Reviews and Original Research articles that cover, but are not limited to the following topics:
● The mechanisms of bone metastasis: the regulation between cancer cells and bone microenvironment cells
● The mechanisms of bone metastasis: the process of cancer cell invasion which is associated with the epithelial-mesenchymal transition
● Identification and validation of prognostic and bone metastatic alternative splicing signatures/ceRNA/immune signatures/cancer stemness signatures in specific tumors based on multi-omics analysis
● Single center/multicenter clinical case series to identify the clinical features/prognostic factors/therapeutic effects of different therapeutic methods in patients with bone metastasis and to develop nomograms bone metastasis and prognosis
● The application of novel techniques, such as single cell sequencing and high-through chromosome conformation capture, in exploring new therapeutic targets of bone metastasis and its underlying mechanisms.
Descriptive transcriptomics studies as well as those consisting solely of bioinformatic investigation of publicly available genomic / transcriptomic data without experimental or in situ validation to support conclusions are not in scope for this Research Topic.
Keywords: bone metastasis, therapeutic strategy, biomarker, bone microenvironment, epithelial-mesenchymal transition, multi-omics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.